Diosgenin Powder Benefits,Uses And Side Effects

What is diosgenin?
Diosgenin powder, extracted from the root of yam, is a natural phytoestrogen. As a steroidal saponin, yam diosgenin has anti-inflammatory, anti-oxidant, anti-diabetic and anti-tumor activities.

Diosgenin is an important raw material for the synthesis of steroid hormone drugs, and is known as one of the two major breakthroughs in the pharmaceutical industry in the 20th century. China and Mexico are the countries with the most abundant diosgenin production in the world, and the production of dioscin accounts for 67% of the world's total production. With the adjustment of Mexico's agricultural structure, China has become the world's largest producer of diosgenin.

 

What Are the Benefits of Diosgenin?(Diosgenin benefits）
1. Drug resistance
In drug-resistant chronic myelogenous leukemia K562 cells, diosgenin can inhibit the drug resistance of various drugs, inhibit the expression of drug resistance gene 1, inhibit the NF-κB signaling pathway, enhance the drug resistance of cells, and at the same time inhibit multidrug resistance The expression of gene 1 promotes the absorption of methotrexate in the intestine of rats, and is widely used as a clinical regulator to enhance the activity of the anticancer agent methotrexate and reduce the gastrointestinal mucosal toxicity caused by methotrexate.
2. Reduce blood fat
Hyperlipidemia is a systemic disease that can accelerate systemic atherosclerosis, cause coronary heart disease, myocardial infarction and other diseases, and seriously threaten people's health. And diosgenin has a strong effect of reducing total cholesterol, triglyceride and low-density lipoprotein, increasing high-density lipoprotein, helping to increase the secretion of cholesterol, promoting the discharge of bile into the intestine, and effectively reducing blood lipids in the body.
3. Anti-atherosclerosis
Yam extract can significantly activate AMPK and inactivate ACC, lower serum cholesterol levels, reduce fatty liver and aortic fat streaks, and effectively resist atherosclerosis.
4. Protect endothelial cell function
Wild yam extract can reduce the expression of VCAM-1 and ICAM-1, reduce the adhesion of monocytes to TNF-α-treated HUVECs, inhibit the NF-κB signaling pathway and the expression of endothelin (ET) to play an anti-inflammatory effect, obviously Inhibits endothelial cell death.
5. Antithrombotic effect
Total steroidal saponins (TSS) from yam root extract can inhibit platelet aggregation (PAG) and thrombus formation, prolong thrombin time, prothrombin time and activated partial thrombin time, improve anticoagulant activity and inhibit PAG, and inhibit thrombus form.
6. Anti-tumor effect
wholesale Diosgenin Powder can inhibit tumor cell division and proliferation, induce tumor cell differentiation and apoptosis, enhance and inhibit the expression of cancer cells, and can also significantly inhibit the growth of leukemia cell lines (K562), induce tumor cell apoptosis, and achieve anti-tumor effects .​​​​​​​

 

Why diosgenin can fight cancer?
Inhibitory effect and mechanism of diosgenin on cancer cells:
The researchers found that diosgenin had a significant inhibitory effect on the growth and growth of liver cancer SMMC-7721, human cervical cancer Hela, and gastric adenocarcinoma MGc80-3 cells. Cytotoxic to the tumor cell line K562 in vitro. Dioscin can inhibit the growth of human leukemia cytokine HL60, induce cell differentiation and apoptosis, and also have obvious effects on the proliferation, cell cycle, apoptosis and cyclooxygenase expression and activity of human osteosarcoma 1547 cell line. The results showed that diosgenin could inhibit the growth of 1547 cells, stop the cell division cycle in G1 phase, and induce apoptosis, thereby effectively inhibiting tumors and cancers.

 

Can Diosgenin Prevent Arthritis?
Diosgenin Extracted from wild yam root can prevent osteoarthritis and rheumatoid arthritis, reduce inflammatory markers, inhibit the occurrence of inflammatory factors, and relieve pain caused by neuropathic inflammation.

 

Can diosgenin fight diabetes?
Dioscin powder can have a positive effect on endothelial dysfunction associated with insulin resistance in an IKKβ/IRS-1-dependent manner, and it can be used to prevent or treat cardiovascular diseases related to insulin resistance and diabetes. Diabetic patients insist on taking diosgenin for a long time Has a hypoglycemic effect, helps restore vascular reactivity, and counteracts lipid peroxidation, apoptosis, and inflammation.
A study showed that after taking diosgenin in diabetic patients, the activity of glucokinase decreased, while the activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase in the liver increased. Appropriate supplementation of diosgenin can significantly reduce the blood sugar level of diabetic patients.

 

What are the uses of diosgenin?
1. Combination drugs of autophagy inhibitors and diosgenin
The combination drug of autophagy inhibitor and diosgenin is composed of one or more safe doses of autophagy inhibitors and diosgenin bulk powder, and its main feature is that it has no obvious cytotoxicity or auxiliary killing effect on tumors. However, the lethality of diosgenin to tumor cells can be enhanced by inhibiting cell phagocytosis, and diosgenin can significantly inhibit the proliferation of tumor cells, induce tumor cell apoptosis and induce tumor cell autophagy, so that the inhibition of cell autophagy can reach a certain level. Significantly enhanced the ability of diosgenin to destroy tumor cells.
2. Vegetable salt of diosgenin
Vegetable salt of wild yam powder diosgenin and preparation method thereof. Dioscorea saponin plant salt has obvious effects of lowering blood fat and blood pressure, and also has laxative effect, improving constipation symptoms of patients, and the effective rate of improving constipation is 84-92%.

Side effects of diosgenin:
Dioscin can improve coronary insufficiency, and also has a certain effect on the treatment of coronary heart disease, angina pectoris, hypertension, high triglycerides, and high cholesterol. However, diosgenin pure powder has certain side effects, and some patients may experience gastrointestinal reactions, so you should consult your doctor when taking it!

 

Where can I buy diosgenin?
Shaanxi Hongda was established in 2003 and is located in Xi'an Economic Development Zone, Shaanxi Province. It is a high-tech enterprise integrating R&D, production, and sales of API raw materials and vitamin drugs. It is a national high-quality diosgenin powder supplier, a large number of wholesale diosgenin, passed a series of official Certifications such as KOSHER, HALAL, ISO9001, ISO22000, US FDA, cGMP, etc., and established a long-term cooperative relationship with well-known foreign pharmaceutical companies. The products radiate to more than 80 countries around the world. Welcome to consult at any time !

 

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Email:duke@hongdaherb.com

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