Alpha Lipoic Acid Powder

Alpha Lipoic Acid Powder (ALA) 99% Purity | Bulk Supply from Manufacturer

Alpha Lipoic Acid Powder (ALA) 99% (HPLC) | CAS No. 1077-28-7 Manufacturer and Supplier Shaanxi Hongda Phytochemistry Co., Ltd. Our ALA is a light yellow crystalline powder with typical sulphurous odour and conforms to USP, EP and JP pharmacopoeias. We deliver to B2B customers in Europe, North America and Asia an annual production of 3,000 tons, an area of 20,000 m² and Certifications such as cGMP, FSSC22000, KOSHER, HALAL, ISO9001 and ISO22000. In stock from our European warehouse, delivery time: 3-7 working days

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What Is Alpha Lipoic Acid Powder?

ALA, also known as thioctic acid or DL-Thioctic Acid, is an organosulfur chemical produced from octanoic acid. It acts as a vital coenzyme in mitochondrial energy metabolism (ATP synthesis) and is generally known as the “Universal Antioxidant.”

What makes it unique is its amphipathic character – it can dissolve in both water and fat, so it can neutralise free radicals in practically every cellular milieu. It also passes the blood brain barrier, making it valuable for neuroprotective formulations.

For manufacturers, demand is driven by three essential functional properties:

· Recycles additional antioxidants such as Vitamins C and E

• Promotes glycemic management by enhancing insulin sensitivity

Aqueous and lipid-based formulations

Products Specification

30 Years OEM factory and manufacturer 

Third-Party Testing

All batches go through in-house testing at our SGS-standardized laboratory before shipment. Equipment includes HPLC, UV spectrophotometer, GC, atomic absorption spectrophotometer, and polarimeter.

Tests conducted on every batch:

· Purity: HPLC assay ≥99.0%

· Melting Point Verification: Confirms purity and absence of degradation

· Optical Rotation: Polarimeter measurement

· Heavy Metals: Atomic absorption spectrophotometry

· Residual Solvents: GC analysis (cyclohexane, toluene)

· Microbiological: Standard USP/EP microbial limits

· Pesticide Residues: Third-party via SGS or Eurofins on request

Batch-level traceability is maintained throughout production.

Key Advantages

Pharmacopeial-Grade Purity

At ≥99.0% assay by HPLC, every gram delivers consistent potency. This matters for dosage-sensitive applications like pharmaceutical tablets or clinical nutraceuticals.

Thermal Stability Management

The 1,2-dithiolane ring is prone to polymerization above 60°C or under direct light. Our production and Packaging protocols specifically address this — double-layer PE bags inside fiber drums protect against heat, moisture, and light exposure during transit.

Solvent-Free Crystallization

Our synthesis process removes residual Class 1 and Class 2 solvents (including cyclohexane and toluene), meeting EP and USP pharmacopeial requirements for clean raw materials.

Flexible Optical Rotation Options

Racemic RS-ALA is available for standard supplement use. R(+)-ALA, the biologically active endogenous form with specific rotation between +110° and +120°, is available for premium formulation needs.

Applications

ALA powder is used across a broad range of B2B product categories:

> For aqueous liquid formulations, sodium lipoate (salt form) is recommended, as the standard powder has low water solubility.

Production Process

Our Alpha Lipoic Acid Powder is produced through controlled chemical synthesis from octanoic acid, followed by ring closure to form the 1,2-dithiolane structure.

Key steps include:

1. Synthesis – Reaction under temperature-controlled conditions below 60°C to prevent polymerization

2. Crystallization – Solvent-free crystallization to eliminate Class 1/2 residual solvents

3. Micronization – Milling to 40–80 mesh for consistent flowability in encapsulation lines

4. Quality Testing – HPLC purity, melting point, optical rotation, residual solvents, heavy metals

5. Packaging – Double-layer PE inner bag, fiber drum outer packaging; light and moisture-protected

Production takes place in 100,000-level clean room workshops, with full batch traceability from raw material to finished product.

Why Choose Shaanxi Hongda?

· Factory Direct: 20,000 m² facility, 3,000 tons annual output, no middlemen

· Europe Warehouse Stock: 3–7 working day delivery to EU customers

· Multi-Certification: cGMP, FSSC22000, KOSHER, HALAL, ISO9001, ISO22000, BRC, ORGANIC (EU & NOP)

· SGS Lab On-Site: 20+ professional testers, full traceability per batch

· Established Since 2001: Over 20 years of plant extract manufacturing experience

· Third-Party Verified: SGS and Eurofins available on request

OEM / ODM Support

Shaanxi Hongda supports customized bulk supply and finished product development.

What we can customize:

· Purity grade: standard RS or high-purity R(+) form

· Particle size: mesh adjustments for tablet compression or capsule filling

· Packaging format: relabeled drums, private label packaging, small sample packs (20–100g aluminum foil bags)

· Finished dosage forms: hard capsules, soft capsules, tablets, premix powders

Minimum sample quantities are available for formulation testing. Our R&D team can assist with stability data and compatibility assessments upon request.

FAQ

Q1: What grade of purity does your ALA powder meet?

A : Our ALA powder is ≥99.0% tested by HPLC on a dry basis and is in compliance with the pharmacopeial standards of USP, EP and JP.

Q2: What is the difference between R(+)-ALA and RS-ALA?

A. RS-ALA is a racemic combination and is what is typically used in OTC supplements. R(+)-ALA is the naturally occurring, biologically active form, with specific rotation of +110° to +120°, preferred for premium or clinical grade products.

Q3: How to store ALA powder?

A: Store in a cool, dry place away from direct light and heat. Do not exceed 25 °C. The 1,2-dithiolane ring is susceptible to polymerisation at temperatures above 60 °C or upon prolonged light exposure which reduces the quality of the product.

Q4: Is your product suitable for the EU and US markets?

A: Yes, that is right. Our ALA conforms to EP and USP requirements. We have FSSC22000, ISO22000, cGMP, ORGANIC (EU) and BRC certifications to support EU and US regulatory standards.

Q5: Do you have samples before bulk order?

A: Yes. Sample sizes 20-100g available in aluminium foil bags. Get in touch with us to schedule a sample shipment.

Q6: What’s MOQ and lead time?

A: The standard MOQ is 25 kg (1 drum). Stocked products — Lead time 3-7 working days with stock in Europe warehouse.

Contact Us

Ready to source high-purity Alpha Lipoic Acid Powder? Send your inquiry to duke@hongdaherb.com and get a quote within 24 hours.