Ursodeoxycholic Acid vs TUDCA

Ursodeoxycholic acid and Tauroursodeoxycholic acid

 

Cholelithiasis refers to a disease in which stones occur in the gallbladder, intrahepatic duct, or common bile duct. Cholelithiasis refers to stones that occur in the gallbladder. Among adults worldwide, the incidence of cholelithiasis is 10% to 15%, with significantly more women than men, with a male-to-female ratio of approximately 1:2.5. Chenodeoxycholic acid, ursodeoxycholic acid and tauroursodeoxycholic acid are all effective drugs for the treatment of gallstones. What is the difference between them?

 

what is udca medication?
Ursodeoxycholic acid UDCA Powder is a white powder, odorless, bitter, soluble in ethanol, insoluble in chloroform, soluble in glacial acetic acid, soluble in sodium hydroxide test solution, melting point is 200 ~204℃. Ursodeoxycholic acid powder is a new pharmaceutical agent specifically designed to treat liver diseases and currently has certain antiviral potential.

What is taursodeoxycholic acid?
The chemical name of tauroursodeoxycholic acid TUDCA is 3α, 7β dihydroxycholanyl-N-taurine, which is formed by shrinking the carboxyl group of ursodeoxycholic acid (UDCA) and the amino group of taurine. A conjugated bile acid, TUDCA Bulk Powder is mostly used to treat gallbladder cholesterol stones, primary sclerosing cholangitis, primary biliary cirrhosis and chronic hepatitis C virus. Compared with ursodeoxycholic acid, tauroursodeoxycholic acid powder dissolves stones more quickly.

What is chenodeoxycholic acid?
CDCA chenodeoxycholic acid is a white to light yellow powder, almost insoluble in water, easily soluble in ethanol, glacial acetic acid, and slightly soluble in chloroform. Chenodeoxycholic acid CDCA is extracted from the bile of chickens, ducks, geese, etc. A bioactive molecule used for the prevention and treatment of cholesterol gallstones and hyperlipidemia, with strong efficacy against pigment stones and mixed stones.

The effects of chenodeoxycholic acid, ursodeoxycholic acid and tauroursodeoxycholic acid:
benefits of ursodeoxycholic acid:
1. Treat gallstones
Ursodeoxycholic acid powder can reduce the content of cholesterol in bile, reduce the saturation of cholesterol in bile, increase the excretion of cholesterol in bile, quickly dissolve stones, and prevent and treat cholesterol stones.
2. Treat liver diseases
Ursodeoxycholic acid UDCA can promote the secretion and secretion of bile from liver cells, improve liver damage caused by bile, reduce bile acid content in the liver, improve stasis liver disease, and can also alleviate liver fibrosis and fatty liver.
3. Treat reflux gastritis
UDCA ursodeoxycholic acid can adjust the acid-base balance in the gastrointestinal tract, reduce the activity of gastric proteases, reduce food irritation to the gastric mucosa, and treat gastric inflammatory diseases.
4. Cell protection, reducing hydrophobic bile acid toxicity
As a hydrophilic bile acid, UDCA can combine with the non-polar structure of the cell membrane, reduce the polarity of the cell membrane, become the main bile acid in serum and bile, and reduce the toxicity of toxic bile acids to liver cells.
5. Inhibit cell apoptosis
UDCA powder can prevent the translocation of the apoptotic protein Bax, inhibit the release of cytochrome C, and avoid cell apoptosis.

 

the benefits of tudca:
Tauroursodeoxycholic acid is mainly used clinically to treat gallbladder cholesterol stones, primary sclerosing cholangitis, primary biliary cirrhosis and chronic hepatitis C virus.

 

Chenodeoxycholic Acid Benefits:
The main function of cholic acid and chenodeoxycholic acid is to reduce the saturation of cholesterol in bile, restore the state of micelles, and dissolve and shed cholesterol in stones. Large doses of CDCA can inhibit the synthesis of cholesterol and increase bile secretion in patients with cholelithiasis. 

 

So, is ursodeoxycholic acid the same as taursodeoxycholic acid?
Although ursodeoxycholic acid and tauroursodeoxycholic acid are both extracted from bear bile, their effects are different. The effect of TDUCA is better than that of DUCA, as follows:

Ursodeoxycholic acid Powder
1. Uses and benefits: UCDA powder is used to treat cholesterol gallbladder stones, which must be X-ray transparent stones; cholestatic liver diseases, such as primary biliary cirrhosis, alcoholic fatty liver and non-alcoholic fatty liver ; Bile reflux gastritis, etc.
2. How to use ursodeoxycholic acid?
For cholesterol gallbladder stones, you can take 10 mg per day according to your body weight, once every night, and a course of treatment is required for 6-24 months.

Taursodeoxycholic Acid Powder:
1. Benefits and uses: TDUCA powder is used to dissolve one or more visible cholesterol stones with a diameter of less than 2cm in the gallbladder or bile duct.

2. How to use tauroursodeoxycholic acid?
For dissolving cholesterol stones, TDUCA can be taken 5-10mg per day according to body weight, divided into 2-3 times after meals, and the course of treatment needs to last for more than 3-4 months.

Generally speaking, UDCA as a single drug is widely used in various hepatobiliary diseases, while bezoar-ursodeoxycholic acid is more used in diseases such as acute hepatitis that require anti-inflammatory and analgesic effects.

 

Are ursodeoxycholic acid and chenodeoxycholic acid the same?
The difference between chenodeoxycholic acid and ursodeoxycholic acid:

Chenodeoxycholic acid can inhibit the intestinal absorption of water and cause diarrhea, while ursodeoxycholic acid powder has a low incidence of diarrhea; chenodeoxycholic acid has a certain toxic effect on the liver and can cause an increase in serum aminotransferases.
Ursodeoxycholic acid is a small molecule substance extracted from bear bile. It has anti-oxidative stress effects when chronic liver diseases occur. It is used to reduce liver damage caused by bile acid retention, improve liver function, and alleviate chronic diseases. happened. For patients with primary biliary cirrhosis, ursodeoxycholic acid can improve patient survival rate and should be given as soon as possible after diagnosis.

 

What are the side effects of ursodeoxycholic acid?
Some patients may experience adverse reactions such as bradycardia, diarrhea, nausea, and vomiting after taking ursodeoxycholic acid. These are usually mild and can be relieved on their own. However, if the adverse reactions are serious, the patient needs to seek medical treatment in time.

Conclusion
As a new effective drug for liver diseases, ursodeoxycholic acid can treat a variety of liver damage and cell metabolism problems. It can also relieve stomach pain and gastritis to a certain extent, and is the nemesis of the new coronavirus; while Tauroursodeoxycholic acid powder is mostly used for acute hepatitis diseases, and its effect is better than that of ursodeoxycholic acid and chenodeoxycholic acid. If you are interested in our products or want to know more product information, you can Contact Us by duke@hongdaherb.com at any time. We are a 30-year high-tech UDCA powder manufacturer specializing in plant extracts and API raw materials. We have our own warehouses in Europe and America , you can purchase at any time!