Understanding The Benefits Of Tildipirosin In Livestock Health

Maximizing Productivity and Animal Welfare with Tildipirosin Treatment

 

With the development of society, the number of people raising pets or animals is increasing day by day, and they regard pets as companions in their daily lives. However, pets occasionally get sick, so Tidipirosin powder is a new type of animal antibiotic drug raw material, which is a broad-spectrum Antibacterial agents are of great benefit to pets or livestock. Next, let’s learn more about Taidirosin!

 

What is Tidipirosin?
Pure tidipirosin is a new animal-specific macrolide antibiotic and a derivative of tylosin powder. The veterinary drug Titilosin is a broad-spectrum antibacterial raw material that is effective against Gram-positive bacteria and some pathogenic bacteria. It is effective against Langerhans-negative bacteria and is especially suitable for diseases caused by pathogenic bacteria of respiratory diseases in pigs, cattle and sheep. Respiratory diseases of pigs, cattle and sheep can lead to slow growth, reduced feed conversion rate and even death, and our Tedirol It is especially suitable for various respiratory disease infections in animals or pets.

 

So, the antibacterial properties of tidipirosin:
1. Wholesale Tidipirosin is effective against pathogenic bacteria that cause respiratory diseases in pigs and cattle (such as Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, and Mannheimia hemolytica). The antibacterial activity of tilmicosin is 2 to 32 times that of tilmicosin, and its antibacterial activity against Escherichia coli is much higher than that of tylosin and tilmicosin.

2. Tildipirosin veterinary also has an effect on certain mycoplasma strains, spirochetes, Brucella, etc. Studies have shown that pure tedirosin has a much higher antibacterial effect on Haemophilus parasuis and Bordetella bronchiseptica than fluoride. Benicol has relatively weak antibacterial effect on Actinobacillus pleuropneumoniae and Pasteurella multocida.
3. Tidipirosin api powder is bactericidal against certain bacteria (such as Haemophilus parasuis and Actinobacillus pleuropneumoniae), and has the strongest effect against certain bacteria (such as Pasteurella multocida). The pH value of bacteria can be reduced from 7.3 to 6.7, and the pH value of Salmonella Enteritidis and Escherichia coli can be increased from 2 to 8ug/mL to 64 to 256ug/mL, which can effectively enhance the intestinal health of animals.

 

What pharmaceutical research has been done on Tidipirosin?
1. Antibiotic drug tildipirosin is fat-soluble and can be quickly absorbed and distributed into various cell tissues. Tedirosin is absorbed quickly in pigs and has a long elimination half-life. It can maintain a high blood concentration for a long time after taking it. Continuous administration of small doses can reach steady-state concentration in a short period of time. The drug is rapidly absorbed and distributed to the infected parts of the lungs and bronchus, quickly inhibiting Pasteurella multocida.
2. After water-soluble tildipirosin is injected into subcutaneous tissue, it is concentrated in the lung and bronchial fluid. After pigs are injected intramuscularly with tedirosin, the drug concentration in the plasma will initially be lower than that in the tonsils. After 24 hours, the drug concentration in the tonsils is higher than that in the plasma. 75 times the concentration, the concentration of tedirosin in the lungs exceeds the MIC90 of Bordetella bronchiseptica (4ug/mL) for about 1 day, and exceeds the MIC90 of Haemophilus parasuis and Pasteurella multocida (1ug/mL). mL) for about 15 days, exceeding the MIC90 of Actinobacillus pleuropneumoniae for about 8.5 days. Therefore, after taking tedirosin, the average drug concentration in the plasma of pigs continues to exceed the MIC90 of most sensitive bacteria for more than 15 days, which can effectively inhibit respiratory disease infections.
3. Tildipirosin soluble powder has good efficacy against intracellular infected bacteria. Compared with goats, sheep undergo subcutaneous injection. The effective absorption of tediroxin is lower, but it is still considered to be high, mainly because sheep Different from the local blood circulation at the subcutaneous injection site in goats; after subcutaneous injection of tedirosin in mice, the plasma drug concentration reaches the peak within 5 minutes, and the infectious bacteria in the cells can be quickly eliminated.

 

What animals is tidipirosin suitable for?
Tidipirosin powder is a broad-spectrum antibiotic and antiparasitic drug, suitable for a variety of livestock or pets, as follows:
1. Poultry: Tildipirosin CAS 328898-40-4 is very effective in treating respiratory tract infections, digestive tract infections and parasitic infections in chickens, ducks, geese and other poultry. It can not only cure diseases but also improve the immunity of poultry and enhance disease resistance. ability.
2. Pigs: Tildipirosin 99% has a good effect on respiratory diseases, digestive tract diseases and parasitic infections of pigs, especially porcine epidemic diarrhea, pig strongylosis, etc., and Tedirosin can also Promote the growth and development of pigs and improve their feed utilization.
3. Ruminant animals: Anti-Infection tildipirosin has good curative effect on respiratory tract infections, gastrointestinal infections and parasitic infections in ruminants such as cattle and sheep, such as oral ulcers and xerotic cow disease, and can also improve the health of ruminants. Digestive function, increase protein utilization.
4. Domestic pets: Tildipirosin veterinary drug has a good preventive and therapeutic effect on common respiratory infections, digestive tract infections and parasitic infections in pets such as cats and dogs.

 

How should we use tidipirosin for our domestic pets?
Before using tidipirosin pure powder for pets, you need to determine the pet's weight and condition. According to the veterinarian's recommendation, 2.5 mg to 5 mg per kilogram of body weight. We can mix the powder in food or dissolve the powder in a small amount of water. , use a syringe or dripper to inject the drug solution directly into the pet's mouth. It needs to be used continuously for 3-5 days to completely treat the pet's infectious disease.

 

So, is tidipirosin safe as an antibiotic?
Our natural tidipirosin is a safe and long-acting broad-spectrum antibiotic. It is more effective than tylosin, tilmicosin and other macrolide drugs widely used in the market. It has rapid absorption and high bioavailability. High efficiency and low residue.
Clinical trials have shown that a single intramuscular injection of tildipirosin USP/Ep/Bp pharmaceutical raw material has a rapid and good control effect on the symptoms of sick pigs. Symptoms such as fever, dyspnea, depression, loss of appetite and other symptoms of sick pigs will be quickly eliminated after administration. Compared with other antibiotic drugs, tedirosin has fewer adverse reactions and is safer.

 

Are tidipirosin and tylosin the same?
Although both tildipirosin bulk and tylosin powder are antibiotic drugs, there are certain differences:
The main ingredient of tediloxin powder is tylosin, which is a kind of antibiotic and has broad-spectrum antibacterial effect. The main component of Tylosin powder is tetracycline antibiotics, which can inhibit the growth and reproduction of a variety of bacteria.
Tildipirosin can only be used in the field of animals or pets and cannot be used in the field of human medicine. Water-soluble tylosin also has certain applications in the field of human medicine.

 

Conclusion
Tildipirosin is a broad-spectrum antibiotic drug for animals or pets with strong antibacterial properties. It is mostly used for respiratory disease infections, bronchitis, lung infections and other livestock or pets such as pigs, cattle, sheep, chickens and dogs. The treatment and prevention of bacterial infections, etc., has multiple benefits for animals.
Shaanxi Hongda is a high-quality Tidipirosin powder factory. It has been awarded the title of National GMP Veterinary Drug Factory and EU Veterinary Drug High-tech Enterprise. Our products are strictly produced in accordance with GMP standards, with assured quality, low residues and high safety, and have long-term service around the world. There are hundreds of companies. If you have any needs, you can Contact Us duke@hongdaherb.com at any time or visit our official website to find your product.

 

Reference:

1、Galecio, J.S.; Escudero, E.; Cerón, J.J.; Crescenzo, G.; Marín, P. Pharmacokinetics of Tildipirosin in Ewes after Intravenous, Intramuscular and Subcutaneous Administration. Animals 2020, 10, 1332. https://doi.org/10.3390/ani10081332

2、Leonardo Bringhenti ,Mariana Pallu,Josiane Silva,Tiago Tomazi,Ana C. Tomazi,Marjory X. Rodrigues,Livia M. Duarte,Todd R. Bilby, Rodrigo C. Bicalho.Effect of metaphylactic administration of tildipirosin on the incidence of pneumonia and otitis and on the upper respiratory tract and fecal microbiome of preweaning Holstein calves.

3、Jincheng Xiong, Yuliang Xu, Shuang He, Yanfang Zhang, Zile Wang, Sihan Wang, Haiyang Jiang.Pharmacokinetics and bioavailability of tildipirosin in rabbits following single-dose intravenous and intramuscular administration.