Global Supply Solution for Pharmaceutical-Grade DMSA Dimercaptosuccinic Acid High-Purity Raw Materials

Purity Standard (HPLC): Greater than 99.0% / 99.5% – Strict control of free sulfur and heavy metal residues.
Main Applications: Clinical chelation therapy for heavy metal (lead, mercury, arsenic, antimony) poisoning; radioisotope imaging (DMSA scintigraphy).
Compliance: Products comply with USP/EP pharmacopoeia standards, with complete stability test data and solvent residue control (ICH Q3C).
Directed cis-Isomeric Synthesis: We employ precise catalytic hydrogenation and acidification processes to ensure that the generated DMSA is in a stable meso configuration. This configuration has the highest coordination affinity when penetrating cell membranes and capturing soft basic heavy metal ions (such as mercury and lead).
Antioxidant Physical Encapsulation: Addressing the susceptibility of thiol groups to air oxidation, our production line operates under full nitrogen protection. Immediately after micronization, the raw material is vacuum-sealed in aluminum foil to ensure that disulfide polymerization does not occur during its 24-month shelf life, maintaining 100% chelation efficacy.
Extremely low impurity profile control: Through multi-stage recrystallization purification, we control synthesis byproducts and inorganic sulfur impurities to below 0.1%, significantly reducing the rate of gastrointestinal adverse reactions in end-user patients during clinical administration.

Dimercaptosuccinic Acid Suppliers

What Is Dimercaptosuccinic Acid ?

DMSA Dimercaptosuccinic Acid is widely recognized as the "gold standard" for measuring the synthetic purity and pharmacological safety of Active Pharmaceutical Ingredients (APIs). As a leading manufacturer of high-purity pharmaceutical intermediates and chelating agents globally, Shaanxi Hongda provides a complete DMSA delivery solution, from laboratory-level R&D (g) to industrial-scale batch supply (MT). By integrating a PLC digital control system and a nitrogen-protected production line, we ensure that the impurity profile control of each batch far exceeds the most stringent requirements of the USP and European Pharmacopoes.

Dimercaptosuccinic Acid

Product Specification

Items	Requirements	Results
Appearance:	White crystalline powder	White crystalline powder
Identification
HPLC	The principal spot obtained with test solution corresponds in position, appearance ,and intensity with that obtained from reference solution.	Conforms
Residue on ignition	≤0.5%	0.32%
Loss on drying	≤ 0.3%	0.05%
Melting Pint	190~194°C	192~194°C
PH	2.5~3.0	2.5
Residual on Ignition	≤ 1000ppm	Complies
Iron(Fe)	≤10ppm	<10ppm
Heavy metal Pb : Cadmium(Cd) : As : Hg:	≤ 10ppm <1 ppm <0.5 ppm <10ppm < 1 ppm	<10ppm Complies 0.3ppm Complies Negative
DMSO content	≤0.01%	0
Assay	≥98%	99.20%
Conclusion:	The product conforms to USP36.

Acid Dimercaptosuccinic Benefits And Applications

1. DMSA Dimercaptosuccinic Acid, a kind of chelating agent, can be combined with metals in the body during detoxification, and then excreted through urine.
2. DMSA reduces levels of toxic metals like lead and arsenic, as well as essential metals like copper and zinc. Some supplements are often prescribed with DMSA.

3.Wholesale Dimercaptosuccinic Acid powder capsules can be compounded in multiple strengths to meet each individual patient's needs.

4.Dimercaptosuccinic is used to rescue lead, mercury, arsenic, nickel, copper and other metal poisoning. Good effect on lead poisoning. It can be used in the treatment of hepatolenticular degeneration.

Strategic Solutions for Global Buyers:

Shaanxi Hongda is not just a manufacturer, but also a partner solving your global market access challenges:

1. Customized Particle Size:

We support micronization services, assisting formulation manufacturers in optimizing capsule filling uniformity and dissolution profiles.

OEM service

2. Fully Transparent Documentation Support:

We provide complete Certificates of Account (COA), stability study data, heavy metal fingerprints, and MSDS. Our familiarity with FDA and EMA filing procedures can help your brand shorten the filing cycle by more than 30%.

laboratory

3. Flexible Logistics System:

For API products, we use pharmaceutical-grade double-layer vacuum light-proof Packaging, supporting temperature-controlled air transport. For core research clients, we support flexible supply solutions with orders starting from 1kg.

packaging

FAQs:

Q1: How do you guarantee the stability of your DMSA during long-distance transportation?

A: Our DMSA undergoes rigorous stability testing (40°C/75% RH) before leaving the factory. By adding pharmaceutical-grade antioxidant inner packaging and triple vacuum aluminum foil layers, we ensure that the thiol content will not significantly degrade even during transoceanic sea transport.

Q2: Is there any off-odor issue with the product?

A: Sulfur compounds naturally have a slight odor, but our high-purity extraction process effectively removes small-molecule volatile sulfur impurities. If used in oral formulations, our powder has an extremely faint odor, making it very easy to mask with flavoring.

Q3: Do you support customized third-party testing for specific batches of ingredients?

A: We have long-term collaborations with international third-party institutions. If you have specific pharmacopoeia standards requirements (such as Germany or Japan), we can conduct targeted testing according to your requirements.

Contact Us

In the chelating agent raw material industry, the level of impurity control determines the clinical safety boundary. Shaanxi Hongda has prepared the latest DMSA Dimercaptosuccinic Acid raw materials for you. Please Contact Us:duke@hongdaherb.com.