Benfotiamine Bulk Powder

Benfotiamine Bulk Powder | Fat-Soluble Vitamin B1 Derivative for Supplement & Pharma Formulations

Shaanxi Hongda Phytochemistry Co., Ltd. provides pharmaceutical grade Benfotiamine Bulk Powder with purity specification 98%-102% (HPLC), CAS No. 22457-89-2. Hongda is a specialised manufacturer created in 2001, more than 10 manufacturing lines in a 20,000 m2 factory with 100,000-level purification workshops, the yearly output of 3,000 tons. The product is certified as KOSHER, HALAL, BRC, ISO9001, ISO22000 and ORGANIC. It provides delivery in 3-7 working days and 25 kg/drum Packaging to supplement brands, contract manufacturers and pharmaceutical formulators across Europe, North America and Asia.

Product Introduction

Benfotiamine is a synthetic fat soluble derivative of Thiamine (Vitamin B1) and is categorised as an S-acylthiamine precursor. Its chemical formula is C₁₉H₂₃N₄O₆PS and molecular weight is 466.45 g/mol.

Unlike regular Thiamine HCl, the molecule has an open thiazole ring structure. This structural difference permits passive diffusion through intestinal membranes and leads to a bioavailability of up to 3.6 times higher than typical water-soluble B1.

It is absorbed and then converted intracellularly into active Thiamine Pyrophosphate (TPP). It is often utilised as a high titer intermediate medication for advanced glycation end product (AGE) inhibition and neuropathic metabolic support.

Product Specification 

23 years  API Product manufacturer 

Third-Party Test Report

Shaanxi Hongda partners with two globally recognised testing companies, SGS and Eurofins, to ensure the authenticity and safety of every batch of goods.

Third party testing includes tests for pesticide residues, nutrition labelling, natural origin reports, particular optical rotation and any customised testing you desire. Authenticate by cross referencing the peaks of HPLC chromatogram with that of the reference standard IR spectrum.

For your compliance assessment, please Contact Us directly to get the latest third party testing report.

Product Advantages

Higher bioavailability, lower dosage requirement. The open thiazole ring structure allows it up to 3.6× higher absorption than Thiamine HCl, so your completed product delivers more active B1 per milligram. 

Excellent thermal stability.It melts at 200°C-210°C. It is superior to Thiamine mononitrate in high temperature processing. It can be used in tablet compression and encapsulation without substantial deterioration.

Stable in lipid matricesUnlike hygroscopic Thiamine HCl, it is stable in non-aqueous settings, making it a prime candidate for long-shelf-life softgel formulations.

"Clean label profile"Allergen Free, GMO Free, Gluten Free, 100% Synthetic – confirmed with COA evidence from recognised manufacturing lines.

Vegan-friendly.The synthetic pathway contains no reagents produced from animals and so is compatible with vegan certification of product lines.

Application Areas

This substance is utilised across a range of B2B formulation categories: 

· Diabetic neuropathy supplements: Benfotiamine + ALA (Alpha-Lipoic Acid) industry-recognized combo for neuropathic metabolic support

· Neurological health capsules/tablets: Clinical dosage range of 150-600 mg/day; 300 mg capsules are standard for neuropathy-related therapeutic claims

· Softgel formulations: Preferred ingredient for softgels with long shelf-life due to superior lipid-matrix stability

· Functional food & beverage: Need emulsification or nano-encapsulation technology for water-based forms due to hydrophobicity

· Pharmaceutical intermediates: High titer grade for pharmaceutical grade processes

Certificate of Analysis (COA)

With every order of our Benfotiamine Bulk Powder you will receive a full COA. The document contains:

· Physical testing Appearance Smell Bulk density Particle size

· Chemical tests: purity (HPLC), loss on drying, ash content, solvent residues

· Heavy metals: lead, mercury, arsenic, cadmium – all within international safety limits

· Microbiological tests: E. coli, yeast, mould, Salmonella, total plate count

Each batch may be tracked from raw material intake to final distribution. The COA can be provided upon request prior to placing your order.

Why Choose Shaanxi Hongda?

· Established manufacturer 2001 with 20,000 m2 facilities and 3,000 tons annual capacity

· In-house laboratory standardised by SGS, with 20+ R&D and QC team

· Multi-standard Certifications: cGMP, FSSC22000, ISO9001, ISO22000, HALAL, KOSHER, BRC, ORGANIC (EU & NOP)

· Third-party verification on all product categories by SGS and Eurofins

• Fast delivery: 25kg/drum, 27 drums/pallet, ready for high volume orders, 3-7 working days

· Full documentation support: COA, TDS, MSDS, third party reports and customs paperwork

 

 

Shaanxi hongda phytochemistry Co.,LTD

Shaanxi Hongda Phytochemistry brings over 20 a long time of ability in characteristic compound fabricating. Our 20,000 square meter office houses 10 cutting edge generation lines with 100,000-level decontamination workshops. We keep up yearly generation capacity of 3,000 tons, guaranteeing dependable supply for your trade needs.

Our group incorporates 20+ professor-level R&D staff who persistently improve and optimize our forms. We've earned acknowledgment as a "National High-tech Improvement Venture" and hold different licenses for our technologies.

You advantage from our broad certification portfolio and strict quality benchmarks. Our 3,000 square meter distribution center keeps up satisfactory stock for opportune conveyance. We offer adaptable bundling alternatives and OEM/ODM administrations to meet your particular requirements.

 

280+

Team Members

 

15+

Certifications

 

25+

Experience

 

10+

Production Lines

Production Process

Shaanxi Hongda manufacture is carried out in a methodical workflow at 100,000-level purification workshops:

Raw material sourcing → synthesis & reaction control → crystallization → drying (moisture ≤1.0%) → milling & particle size classification → in-process QC (HPLC, UV, GC) → final quality inspection → vacuum-sealed HDPE drum packing → batch documentation & shipment. 

Each stage is checked by the in-house QC staff utilising HPLC, UV spectrophotometry, and GC instruments.  The facility is cGMP and FSSC22000 certified (both new in 2025) to assist pharmaceutical and functional food customers in regulated markets.

Our Factory

cGMP standard producing process, making sure the best quality of product

OEM / ODM Support

If you require more than a raw powder, Shaanxi Hongda offers complete OEM and ODM customisation.

Finished product formats include softgels, hard capsules, tablets and pre-mixed powders.Your formulation can mix Benfotiamine with additional actives such as Alpha-Lipoic Acid, B-complex vitamins, or other neuropathic support substances. 

We offer private label packaging, unique specifications and formula formulation. Each project is carried out in an aseptic production setting, directly with the R&D team.

FAQ

Q1: How does lipid solubility influence formulation design?

A: It is sparingly soluble in water and stable in lipid matrices. Liquid formats need particular emulsifiers or nano-emulsion technologies to avoid precipitation.

Q2: Can it be co-formulated with Alpha Lipoic Acid?

A: Yes, it is. Benfotiamine + ALA is an industry-standard combination for diabetic neuropathy formulations. Particle size matching is desirable to avoid segregation during blending.

Q3. What is the recommended dosage range of the final dosage form?

A: Clinical data suggest 150–600 mg/day. B2B formulators are targeting 300 milligrammes per capsule for neuropathy claims.

Q4: Is it good for vegan products?

A: Okay. The synthetic synthesis technique does not employ any animal-derived reagents, therefore it is compatible with vegan-certified supplement lines.

Q5: When should bulk stock be stored to preserve shelf life of 24-36 months?

Q: Where do you keep it? A: In original vacuum sealed HDPE drums, protected from direct light and moisture, at cool and dry temperature. Do not open the drum repeatedly.

Q6: How to check COA authenticity before purchase?

A: Match the peaks in HPLC chromatogram with the reference standard and check the IR spectra. We also supply third party reports from SGS and Eurofins on demand.

Contact Us

Ready to source pharmaceutical-grade material with Benfotiamine Bulk Powder? Send your inquiry to duke@hongdaherb.com and our team will respond within 24 hours.