Levamisole Hcl Powder

Levamisole Hcl Powder | High-Purity API for Veterinary & Pharmaceutical Use | 99% Purity Guaranteed

Pharmaceutical Grade Levamisole Hcl Powder 99% Powder - CAS 16595-80-5 - Shaanxi Hongda Phytochemistry Co., Ltd. USP, EP, BP. Founded in 2001, Hongda is a manufacturer with 20,000 m2 for production, 100,000 level purification workshops and annual production capacity of 3,000 tons. White crystalline powder (melting point 226-231°C, specific optical rotation −121° to −128°) (CAS: 16595-80-5) Hongda is certified with cGMP, ISO9001, ISO22000, Halal, Kosher and FDA. We supply traceable and GMP compliant API raw ingredients to veterinary anthelmintic and immunomodulatory formulation producers across the world.

Product Specification

Product Introduction

Levamisole Hcl Powder is the hydrochloride salt form of Levamisole, chemically identified as (S)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride. Its molecular formula is C₁₁H₁₂N₂S·HCl, with a molecular weight of 240.75 g/mol.

It is the levorotatory (L) enantiomer of tetramisole — not a racemic mixture. This distinction matters: the L-isomer carries the anthelmintic activity with approximately half the toxicity of the racemate, making it the preferred form for formulation-grade API use.

The compound acts as a nicotinic acetylcholine receptor agonist in nematodes, causing spastic paralysis and expulsion. It also functions as a biological response modifier, restoring depressed immune function — making it a dual-action API used in both veterinary medicine and immunological research.

Third-Party Test Report

All production batches are tested in Hongda's SGS-standardized internal laboratory before shipment. Testing equipment includes HPLC, GC, UV spectrophotometers, atomic absorption spectrophotometers, and polarimeters.

For independent verification, Hongda cooperates with authorized third-party agencies including SGS and Eurofins for:

· Pesticide residue detection

· Residual solvent analysis

· Specific optical rotation confirmation

· Heavy metal testing

· Microbiological testing

Third-party test reports are available upon request for each batch.

Levamisole Hcl Powder Advantages

Pure L-Isomer, Not Racemic

The product is confirmed as the levorotatory enantiomer via polarimetry. Specific optical rotation of −121° to −128° guarantees enantiomeric purity — directly reducing D-isomer-related toxicity risk in finished formulations.

High Water Solubility for Versatile Formulation

Approximately 1 part dissolves in 2 parts water, supporting formulation into injectable solutions, oral drenches, water-soluble powders, and boluses without solubility limitations.

Stable in Acidic Conditions

The compound remains stable in acidic pH environments, which aligns with the gastrointestinal environment in livestock. However, it hydrolyzes under alkaline conditions — a formulation consideration your team should factor in during pH selection.

Pharmacopoeial Compliance

Purity exceeds 99.0% with strict control of related substances (imidazolines) and residual solvents, meeting USP, EP, and BP standards.

GMP-Documented Supply Chain

Synthesis routes, solvent usage, and production traceability are fully documented. Open parts of DMF/VMF support are available for regulatory submissions.

Levamisole Hcl Powder Application

Veterinary Anthelmintic Formulations

Used as the primary API in manufacturing deworming products for cattle, sheep, and swine. High solubility supports production of stable injectable solutions and water-soluble powders effective against lungworms and gastrointestinal nematodes — particularly in herds showing benzimidazole resistance.

Aquaculture Immunostimulant Feed Additives

In intensive fish and shrimp farming, it functions as a feed additive to strengthen non-specific immune responses. This improves survival rates during high-stress events such as transport, temperature changes, or bacterial/viral pathogen exposure.

Pharmaceutical Immunomodulatory Research

Used in producing adjuvant therapies intended to restore depressed immune function. It is also referenced in specific oncological combination therapy research. Human pharmaceutical applications are strictly regulated — confirm applicable regulatory requirements in your target market.

Why Choose Us?

· Established manufacturer since 2001 with 20+ years of API production experience

· 3,000-ton annual capacity ensuring consistent supply for large-volume orders

· SGS-standardized laboratory with 20+ R&D and QC professionals on-site

· Multi-standard Certifications: cGMP, ISO9001, ISO22000, FSSC22000, Halal, Kosher, BRC, FDA, Organic (EU & NOP)

· Third-party testing via SGS and Eurofins available per batch

· Full traceability documentation supporting VMF/DMF regulatory submissions

· Responsive technical support — one-to-one service for formulation questions and compliance documentation

 

 

We are always at your service when you need

Shaanxi Hongda was established in 2001.  We are a manufacturer specializing in raw materials for veterinary drugs for animals and poultry. We mainly produces florfenicol, amoxicillin, enrofloxacin, metronidazole, abamectin, and tilmicol. Xing and other veterinary drug powders, premixes, granules, etc. are produced in strict accordance with international veterinary drug raw material standards, and all qualification certifications are complete. Welcome to cooperate with us!

 

280

Time members

 

30+

years experience

 

15+

Certifications

 

10

Workshop Production Line

Production Process

Hongda's production follows a documented GMP workflow:

1. Raw material intake — incoming inspection including identity, purity, and heavy metal screening

2. Synthesis and extraction — controlled reaction environment in purification-grade workshops

3. Crystallization — producing the white crystalline hydrochloride salt form

4. Drying and milling — controlled temperature to prevent degradation above thermal thresholds

5. In-process quality control — HPLC purity checks and polarimetry verification at each stage

6. Final QC and release — full COA issued before Packaging

Products are manufactured in 100,000-level purification workshops with bioburden controls aligned to injectable-grade API requirements.

Our Factory

OEM / ODM Support

Hongda supports custom formulation development and private-label production. You can request:

· Custom purity specifications or particle size adjustments

· Formulation development into water-soluble powders, injectable concentrates, or premix blends

· Custom packaging with your brand label and specifications

· Small sample orders (20–100g) for testing before bulk commitment

Standard bulk packaging is 25 kg/drum, 27 drums/pallet. Sample packaging uses inner PE bags with outer aluminum foil bags. Lead time for standard orders is 3–7 working days.

Our Exhibitions

Delivery Method

FAQ

Q1: How is Levamisole Hcl differentiated from Tetramisole Hcl in your quality testing?

A: Levamisole is the purified L-isomer of Tetramisole. We confirm this using polarimetry. Levamisole must show a specific negative rotation (−121° to −128°), while Tetramisole is racemic and shows near-zero rotation. This test is performed on every batch.

Q2: What causes the powder to turn yellow, and does it affect potency?

A: Yellowing indicates oxidative degradation, typically caused by light exposure or contact with alkaline contaminants. If the Appearance of Solution test fails (solution not colorless), the batch has likely degraded — both potency and safety may be compromised.

Q3: Can the same material be used for both injectable and oral formulations?

A: Yes. High water solubility and acid-stable properties make it suitable for both. Injectable-grade use requires additional bioburden and endotoxin control. Please specify your intended application when ordering.

Q4: What are the storage requirements to prevent degradation?

A: Store in tight, light-resistant double PE bags inside fiber drums at controlled room temperature. Avoid humidity exposure, which triggers hydrolysis and discoloration.

Q5: Is VMF or DMF documentation available for regulatory submissions?

A: Yes. Hongda provides open parts of DMF/VMF documentation covering synthesis routes, solvent usage, and GMP compliance records — supporting your regulatory submissions in the EU, US, and other markets.

Q6: What is the minimum order quantity, and how quickly can samples be arranged?

A: Samples (20–100g) can be arranged quickly for evaluation purposes. Standard bulk orders ship within 3–7 working days. Contact Us to discuss MOQ based on your specific formulation requirements.

Contact Us

Ready to source pharmaceutical-grade API with Levamisole Hcl Powder? Email duke@hongdaherb.com to request a COA, sample, or quote today.