Colistin Sulphate Powder

High-Purity Colistin Sulphate Powder for Veterinary Antibiotic Applications | Expert Gram-Negative Pathogen Control Solution

Shaanxi Hongda Phytochemistry Co., Ltd. we are a leading producer and supplier of Pharmaceutical Grade Colistin Sulphate Powder providing excellent bactericidal solutions to Veterinary and Animal Health Industries around the world. Our factory has over 20 years of production experience, with more than 20,000 square meters of contemporary production workshops, 100,000-level purification workshops and more than 10 sophisticated production lines. Our product is very potent (>19000 IU/mg) and water soluble, meeting strict EP4 and EP6 criteria. We are certified under cGMP, FSSC22000, ISO22000, Halal and Kosher standards. Our stringent testing requirements for heavy metals, microbiological contaminants and residual solvents ensures constant quality to bring out the best therapeutic benefits for your formulations.

Introduction of Product

This product is a particular polypeptide antibiotic produced by fermentation of Bacillus polymyxa and used in the prevention and treatment of gram-negative bacterial infections in animals and aquaculture. The white hygroscopic powder was effective in disrupting the membranes of Escherichia coli, Salmonella species and Pseudomonas aeruginosa. Its unique pharmacokinetic profile allows it to function locally in the gastrointestinal tract with limited absorption into the systemic circulation. This makes it a perfect choice for the treatment of enteric infections, while ensuring rigorous meat safety compliance in foreign markets.

Colistin Sulphate Powder Advantages

Improved Heat Stability: Our powder remains stable and does not lose potency at pelleting temperatures of up to 85°C. This makes it easy to use in feed production processes and provides complete therapeutic efficacy from mill to animal.

Unmatched water solubility: specifically formulated to dissolve quickly in soft and hard water systems, eliminating nipple drinker clogging and delivering consistent treatment to big poultry and swine operations.

Accurate Polymyxin Composition: Polymyxin E1, E2, E3, E1-I, and E1-7MOA ratio validated using HPLC reduces neurotoxicity risk and enhances bactericidal efficacy answering industry concerns about adverse effects.

Extended Shelf Life – Our hygroscopic control technology and pharmaceutical-grade Packaging provide a 36-month shelf life under optimum storage circumstances, decreasing inventory loss and the frequency of procurement.

Application of Colistin Sulphate Powder

Intensive Poultry Systems: Controls necrotic enteritis and colibacillosis in broilers and layers. Given in medicated water, rapidly restores flock health in 3-5 days at therapeutic gut level levels.

Post-Weaning Swine Management: Targets enterotoxigenic E. coli -induced diarrhoea as a feed additive. Thermal stability enables bioactivity to withstand pelleting processes, ensuring consistent piglet protection.

Aquaculture Pathogen Control: Targets Pseudomonal infections in fish farming by oil-bonded feed pellet coating in which low systemic absorption preserves gut flora without the issue of pollution of environment’s water.

Third Test Report

Microbiological Potency: Potency levels are consistently over 19,500 IU/mg, confirmed by independent SGS laboratory examination, surpassing pharmacopoeia criteria and providing dependable dose estimations for your veterinary formulations.

Heavy Metal Compliance: Eurofins testing confirms our product is compliant with EU and FDA requirements for Lead <2ppm, Arsenic <1ppm, Cadmium <0.5ppm and Mercury <0.1ppm ensuring feed safety standards are met.

Pesticide Residue Screening: Multi-residue analysis of 500+ chemicals indicates non-detectable levels, indicating our controlled fermentation process removes agricultural pollutants.

Why Choose Us?

Shaanxi Hongda integrates vertical production with scientific brilliance via university linkages and ISO certified quality standards. We have automated HPLC, GC and spectrophotometry equipment to make sure that each batch satisfies the criteria of the international pharmacopoeia. Enjoy direct factory prices, no middleman markups, technical help from qualified veterinary pharmaceutical professionals and delivery dependability supported by our 3,000 square metre inventory system. Our Certifications (cGMP, BRC, Organic) show our dedication to regulatory compliance and our three raw material planting bases ensure the security of our supply chain. We’re more than a provider. Partner with us and tap into 20 years of fermentation experience to help you succeed in your market.

Manufacturing Process

Step 1 - Fermentation Cultivation: Bacillus polymyxa strains undergo controlled aerobic fermentation in sterile bioreactors at optimal pH and temperature parameters, resulting in maximum polymyxin yield with consistent composition profiles Colistin Sulphate Powder.

Step 2 - Filtration and extraction: The fermentation broth is run through multi-stage filtration systems to remove cellular debris and then subjected to chromatographic separation to isolate the target polymyxin components, reaching a medicinal purity level of over 98%.

Step 3 - Sulphate Conversion The purified colistin base is reacted with pharmaceutical grade sulphuric acid under carefully regulated circumstances to generate the stable colistin sulphate salt which crystallises consistently to provide outstanding powder properties.

Step 4 - Spray Drying and Milling: Our crystalline product is spray dried at low temperature in our 100,000 grade clean rooms and then jet milled to a particular particle size distribution optimised for feed mixing and water solubility.

Step 5 - Quality Verification & Packaging: Finished product is subjected to a battery of tests such as HPLC potency assay, heavy metal analysis, microbiological analysis etc. and packed in double sealed PE bags in fibre drums to ensure contamination free product delivery.

OEM/ODM Services

Custom Formulation Development. Your technical staff works with our 20+ professor level R&D team to build unique mixes of colistin with synergistic antibiotics such as amoxicillin to increase pathogen coverage for challenging infection situations.

Flexible Packaging Solutions We can adapt to your branding needs with customised barrel sizes (5kg to 25kg), label designs and multi-language paperwork to support a variety of market entrance strategies throughout European, North American and Asian countries.

Pre-Clinical Support Services Utilise our SGS-certified laboratory for your stability studies, compatibility testing with your carrier matrices and regulatory paperwork preparation to accelerate your product registration deadlines.

Scalable Production Capacity: Our 3,000-ton yearly production capacity and dedicated manufacturing campaigns guarantee a steady supply for your seasonal demand peaks and no minimum order penalty for trial batches.

FAQ

Q: How does this product differ from Colistin Methanoate?

A: Colistin Sulphate suits oral administration for enteric infections due to poor systemic absorption, while Methanoate serves as an injectable prodrug for systemic treatment. They are not interchangeable.

Q: Can I combine it with other antibiotics?

A: Yes, it demonstrates synergistic effects with Amoxicillin or Tylosin, expanding coverage to both Gram-positive and Gram-negative bacteria for complex infections.

Q: What about pelleting temperature effects?

A: Our product maintains stability at 70-85°C during standard pelleting processes, preserving potency for feed premix applications.

Q: How should I store it to prevent caking?

A: Keep in tightly sealed containers with double polyethylene liners in cool, dry conditions. Use desiccants in storage areas to control humidity exposure.

Q: What is the minimum order quantity?

A: We support trial orders starting from 100kg while offering volume discounts for pallet quantities (675kg/27 drums), accommodating both new product development and commercial-scale production needs.

Contact Us

Ready to secure pharmaceutical-grade Colistin Sulphate Powder for your veterinary formulations? Contact Us today at duke@hongdaherb.com  to receive detailed quotations, regulatory support files, and personalized consultation on integrating our solutions into your production workflows.