Genistein Extract

Genistein Extract – Premium Isoflavone Supplier & Manufacturer

Shaanxi Hongda Phytochemistry is a prominent manufacturer and supplier of high purity Genistein Extract, offering unparalleled quality to pharmaceutical, nutraceutical and cosmeceutical industries throughout the world. We have over 20 years experience in natural plant extraction. Our modern 20,000 square metre production base is equipped with purifying workshops to 100,000 level, ensuring the product you receive can reach a purity of 98%, validated by HPLC examination. Unlike generic vendors, we oversee the entire production chain. From our dedicated Sophora japonica planting base to final testing in our SGS-certified laboratory, we ensure constant bioavailability and 0% batch-to-batch fluctuation. Our exclusive extraction method removes competing glycosides that reduce efficacy delivering accurately dosed phytoestrogen ingredients for bone health formulas and control of menopausal symptoms. Working with Hongda you will benefit from third party testing, full Certifications including HALAL, KOSHER, cGMP and FSSC22000, and responsive OEM/ODM customisation that helps you get to market faster while still complying with US and European regulations.

Product Introduction

Genistein ​​​​​​​Powder is a high purity isoflavone aglycone, mostly from the dried pods of Sophora japonica L., our well cultivated botanical resource. This off-white powder has 98% genistein content verified by rigorous HPLC techniques, providing you with a pharmaceutical-grade substance without the inconsistency of crude soy isoflavone combinations. This extract is a selective phytoestrogen with a preferential binding affinity to Oestrogen Receptor Beta, providing solutions to the key formulation problems for hormone sensitive applications where specific oestrogenic action is desired. Also our product is exceptional in thermal stability up to 297°C suitable for a variety of manufacturing processes and keeps full potency throughout your production cycle.

Genistein Extract Advantages

Superior Bioavailability Profile: Our proprietary micronization process reduces particle size to 80 mesh standard, greatly enhancing dissolution rates in gastrointestinal fluids compared to standard-grade products, resulting in faster absorption and improved clinical outcomes in your formulations.

Structural Integrity Preservation: Our low temperature vacuum extraction protects the crucial hydroxyl groups at 4', 5 and 7 positions, unlike heat destroyed extracts from poorer processing methods, which results in maximum tyrosine kinase inhibition activity and oestrogen receptor binding affinity.

Solvent Residue Control: Gas chromatography ensures ethanol residues are below 5000ppm, meeting ICH Q3C criteria, avoiding formulation incompatibilities and regulatory hurdles in pharmaceutical applications where solvent purity affects clearance delays.

Long Shelf Life: Built-in antioxidant protection systems during processing result in >95% potency for 36 months, when stored properly, minimising inventory loss and enabling flexible manufacturing scheduling without effectiveness worries.

Genistein Specification

Genistein Extract Application

Menopausal Health Supplements: Formulation scientists incorporate this extract into combination treatments treating hot flashes and night sweats, where its selective ER-beta agonism gives symptomatic relief without endometrial proliferation hazards associated with standard hormone therapy.

Bone Density Preservation Systems: Genistein Extract is utilised by nutraceutical developers in synergistic complexes with calcium, vitamin D3 and minerals, taking advantage of its dual mechanism of stimulating osteoblast differentiation and inhibiting osteoclast activity, which is especially useful in protocols for preventing postmenopausal osteoporosis.

Advanced Skincare Actives: This extract is preferred by cosmeceutical chemists for premium anti-aging serums, since it serves as a tyrosinase inhibitor to combat hyperpigmentation and a collagen synthesis booster, demonstrating visible wrinkle reduction in clinical testing settings.

High-Purity Genistein in Metabolic Research Applications: Pharmaceutical researchers use high-purity genistein as a reference standard in diabetes and obesity studies, where its protein tyrosine kinase inhibitory capabilities provide insights into the modification of the insulin signalling pathway.

Production Process

Step 1 – Selection and Preparation of Raw Materials: We gather the ripe pods of Sophora japonica from our certified organic planting base at the time when the isoflavone content is the highest and then dry them immediately at a controlled temperature of less than 60 degrees Celsius. This maintains the enzymatic integrity and inhibits the oxidation of genistein precursors.

Step 2 – Extraction and Concentration: The pre-treated botanical material was countercurrently extracted using ethanol in our automated system. The solvent was concentrated and optimised by response surface methodology. Result: Most genistein with least co-extraction of flavonoid contaminants.

Step 3 – Purification and Crystallisation: Crude extract is processed in our 100,000 level clean room environment using macroporous resin chromatography and controlled pH crystallisation. Results: > 98% pharmaceutical purity, complete elimination of genistin and daidzein impurities.

Step 4 – Drying and Micronization: Purified crystals are vacuum dried at temperatures confirmed not to exceed the degradation temperature of genistein, then jet-milled to a defined particle distribution. Result: Optimised surface area free flowing powder for enhanced dissolving characteristics.

Step 5 – Quality Verification & Packaging: Final product is subject to a 23-point quality examination, including HPLC fingerprinting, prior to packaging in nitrogen-flushed pharmaceutical grade fibre drums. Result: Stability and traceability guaranteed according to worldwide GMP standards.

Third-Party Test Report

Standards for Independent Verification: Every production batch is fully analysed by world-renowned third party labs such as SGS and Eurofins, providing you with independently confirmed quality documentation that meets regulatory standards in your target countries.

Pesticide Residue Screening: Multi-residue screening to certify compliance with EU regulation limits and USDA organic standards protects your brand from contamination risk that could lead to costly product recalls.

Heavy Metal Profiling: Atomic absorption spectrophotometry for verifying the levels of lead, arsenic, cadmium and mercury at less than 10ppm total threshold, satisfying the most stringent international pharmacopeial criteria for oral supplements.

Microbial Safety Testing: Total plate count, yeast, mould, E.coli and Salmonella testing ensures microbiological purity for straight encapsulation without extra sterilisation processes.

OEM/ODM Support

Custom Specification Development: Our R&D team works with you to develop custom genistein concentrations from 40% to 99% purity to meet your unique bioavailability requirements and cost considerations while still meeting efficacy criteria.

Formulation Technical Support: Our 20+ formulation scientists are available to give stability testing data, excipient compatibility studies, and dissolution optimisation advice unique to your delivery system whether it is a tablet, capsule, or transdermal patch.

Regulatory Documentation Support: Our complete dossiers include DMF compatible documentation, allergen statements, GMO free certifications and country specific compliance letters to facilitate your registration processes in FDA, EMA and Health Canada jurisdictions.

Flexible Minimum Order Quantities: We are not mass producers demanding multi-ton commitments. Our production flexibility allows for trial batches from 25kg, giving you the chance to test the market before scaling up to commercial volumes.

Private Label Packaging Solutions: Select from our packaging choices include custom-printed fibre drums, foil bags with your branding and retail-ready bottles that maintain product integrity while building your brand identification.

Why Choose Us?

You require a partner who knows that product quality is closely tied to the clinical credibility of your product. We have a production capacity of 3,000 tonnes per year and real-time inventory management, so you will not experience any supply problems during high season demand. We have 20 researchers at professor level in our SGS laboratory. They are not only testing items, but also innovating extraction processes. They have won us many national patents and High-Tech Enterprise. Regulatory changes? Our FSSC22000 & cGMP certifications keep your supply chain compliant with no reformulation issues. With our 3 specialised planting bases, we minimise the third party raw material concerns that hinder traceability, offering you full transparency from farm to formula. And most importantly, we know you don’t have time for delays in your production schedules, so our customer support team will answer within 4 hours. By choosing Hongda, you are choosing a manufacturer who is involved in your success – not simply another transaction.

FAQ

Q: How does your product differ from standard soy isoflavone products?

A: Our product contains genistein aglycone ≥98% pure, compared to usual soy extracts that contain mixed isoflavones including glycoside forms with far reduced bioavailability. This purity removes variability in dose and ensures predictable oestrogenic activity.

Q: Is the product suitable for liquid supplement formulations?

A: Due to its poor water solubility, we recommend micronization or co-processing with solubilizers like cyclodextrins. We have a technical staff ready to help you with the formulation details according to your intended dosage and delivery form.

Q: What kind of documents do you supply for overseas shipping?

A: All shipments will include a Commercial Invoice, Packing List, Certificate of Analysis, Third Party Test Reports, Phytosanitary Certificate and any country specific paperwork required, for example FDA Prior Notice certification for exports to the US.

Q: What is your average lead time for bulk order?

A: Stock products will ship in 3-7 business days. Custom specs take 15-20 business days (including certification of stability). Rushed production is possible with adequate notice.

Q: Do you have samples to do formulation trials?

A: Yes we can offer you with 100g samples with full COA paperwork. Please email us your shipping details and intended application at duke@hongdaherb.com for completing your sample request.

Contact Us

Ready to elevate your product formulations with premium Genistein Extract?

Email: duke@hongdaherb.com​​​​​​​