Berberine HCL Powder

Berberine HCL Powder | 97% Purity Standardized Extract | Metabolic Health Raw Material

Shaanxi Hongda Phytochemistry Co., Ltd. is a provider and producer of Berberine HCL Powder with over 20 years production experience. Berberine Hydrochloride (Goldthread, Coptis chinensis) Our berberine hydrochloride is guarantyd to be ≥97% pure (HPLC), CAS No. 2086-83-1. The plant covers an area of 20,000㎡ , with 10+ production lines running in 100,000-level purifying workshops . The delivery time is 3-7 working days following order confirmation . Certifications include KOSHER, HALAL, BRC, ISO9001, ISO22000, cGMP and FSSC22000 – ensuring you have a fully documented, audit-ready supply chain from day one.

Product Introduction

Berberine hydrochloride is a quaternary ammonium isoquinoline alkaloid that is found in Coptis chinensis. The hydrochloride salt form is the industry standard for B2B pharmaceutical and nutraceutical buyers because it has greater chemical stability, solubility and bioavailability than sulphate or free-base forms.

Molecular Formula C20H18ClNO4 Molecular Weight 371.81 g/mol Physically, it is a pale yellow crystalline powder with a very bitter flavour. It is soluble in hot water and ethanol, therefore it is amenable to a variety of processing procedures.

This standardised substance is ≥97% pure (HPLC) and eliminates the variability associated with raw herbal powders. Every batch is guarantyd to have an exact alkaloid content – and that’s important when you’re scaling formulas.

Third-Party Test Reports

Every batch of production is tested by internal quality control and external third-party verification. We have our own laboratory with HPLC, UV and GC equipment according to SGS standards. Testing includes:

· Purity assay – HPLC, not less than 97%

· Heavy metals – mercury, lead, cadmium, arsenic

· Pesticide residue - multi-residue screening

· Microbiological testing - total plate count, yeast, mould

· Ash content, Loss on drying, Particle size

We also partner with accredited agencies such as SGS and Eurofins for pesticide residue testing, nature reports and nutrition labelling. Documents are requested before test order.

Berberine Hcl Specifications

COA (Certificate of Analysis)

Each shipment contains a complete Certificate of Analysis. The COA includes batch number, production date, test results for all major parameters and the signature of the relevant QC.

Need a pre-shipment COA for your regulatory team? Just ask us. We can send it forward so that your compliance evaluation doesn't delay your manufacturing timeline.

Berberine HCL Powder Advantages

1. High Purity, Consistent Potency

Each batch provides consistent active content at >=97% testing by HPLC. This becomes particularly critical for dosage-sensitive metabolic health solutions designed to activate AMPK.

2. Controllable particle size

80 mesh, 95% pass. This consistent particle distribution facilitates even blending in capsule and tablet manufacturing, leading to fewer hot spots and improved dosing accuracy.

3. Stability and Shelf Life of

The HCL salt form is more stable than the free base.  If kept sealed and stored in a cold, dry place it is stable for 2-3 years. Note: the powder is hygroscopic — moisture control during storage is necessary. 

4. Multi-Form Compatible 

It is soluble in hot water and ethanol and so can be encapsulated in softgel capsules, tableted, encapsulated in liposomes and phytosomes for enhanced absorption.

5. Fully Documented Supply 

From planting base traceability to third-party lab findings, every stage is documented.  Your quality team gets everything needed for regulatory submissions. 

Berberine HCL Powder Application

Metabolic Health Supplements

This is the core market. Berberine HCL Powder is a common ingredient in formulae for blood sugar management and lipid metabolism. Due to its high density, producers may fit 500 mg into a capsule or tablet without making the units enormous.

Functional Animal Nutrition

Used in livestock and companion animal feed for gut health control and antibacterial activities.  The powder can survive the heat and moisture of the pelleting process – preserving potency through processing.

Cosmeceutical & Topical Formulations

Used in acne-fighting lotions and serums for their anti-inflammatory and antibacterial benefits. The powder needs to be stabilised and solubilized, and the pH needs to be managed carefully to prevent colour leaching or oxidation.

Use of pharmaceutical APIs

Berberine HCL is in compliance with the CP, EP and USP Pharmacopoeia monographs, therefore providing a viable starting material for registered pharmaceutical goods in several countries.

Production Process

The entire supply chain, from raw material procurement to final packing, is controlled by Shaanxi Hongda.

1. Botanical source - Roots of Coptis chinensis grown in controlled cultivation with agronomists on site

2. Cleaning and pre-treatment – removal of soil, foreign matter and surface contamination

3. Extraction — water or solvent extraction under regulated temperature and time parameters

4. Purification & crystallisation – sophisticated crystallisation technique to reach ≥97% purity; this stage directly tackles the low bioavailability issue common in raw alkaloid materials

5. Drying – controlled drying to LOD ≤12.0%

6. Milling & sieving — particle size adjusted to 95% pass 80 mesh screen

7. QC testing – comprehensive in-house testing before packing

8. Packaging - double layer PE inner bag, fibre drum outer packing, 25kg/drum

Production is carried out in purifying workshops at the level of 100 000. 3,000 tons of annual capacity.

OEM / ODM Support

The opportunity exists for you to move beyond simply buying basic materials. Shaanxi Hongda offers complete OEM and ODM product development for brands starting or expanding in the health supplement market.

Customisation possibilities available are:

· Soft gels, hard shells, pills, pre-mixed powders

• Your private label packaging with your logo

· Formulation development to combine berberine with complimentary substances (ex chromium, cinnamon extract)

· New product launch minimum order quantities revised

The R&D team consists of around 20 skilled individuals from universities and research institutions. One-to-one product development help from concept to finished product.

Why Choose Us?

· Founded in 2001 · 20+ years of plant extract production

• 20,000㎡ facility, 10+ production lines, 100,000 level clean workshops

· Annual output 3000 tons – Enough stock, guarantyd delivery on time

· SGS standard laboratory – HPLC, GC, UV, atomic absorption in house equipment

• Third party verified – Eurofins and SGS for pesticide, nutrition and residue testing

· Certifications: KOSHER, HALAL, BRC, ISO9001, ISO22000, cGMP, FSSC22000, Organic (EU & NOP)

· Traceability: own planting bases, complete batch management

• Flexible logistics 3-7 working days delivery 25kg/drum basic, bespoke packaging available

FAQ

Q1: What is the botanical origin of your berberine?

A: We use the root of Coptis chinensis (Goldthread) as our standard source, due to its reliable alkaloid output and traceability back to our own controlled planting base.

Q2: What is the difference between Berberine HCL and Berberine Sulphate?

A: The HCL form gives you better data on bioavailability, has greater approval by regulators for use in dietary supplements and is more cost effective. It's the favoured form for most North American and European buyers.

Q3: Is it possible to make the powder liposomal or phytosomal?

A: Yes. The particle size (95% pass 80 mesh) is regulated and the purity is ≥97%, which makes it an excellent option for both liposomal and phytosome technologies to improve absorption.

Q4: How can you best control bitterness in beverage applications?

A: The raw powder is quite bitter and cannot be used in liquid drinks as it is. For beverage applications, the recommended options include micro-encapsulation or bitterness-masking chemicals.

Q5: What are the storage and shelf life conditions?

A: Store in a cool, dry area, away from light in a closed container. Under these conditions the product remains stable for 2-3 years. It needs management of humidity as it is hygroscopic.

Q6. Can you supply samples before bulk order?

A: Yes. Sample packaging available in 20-100g (inside PE bag + exterior aluminium foil bag or carton). Please Contact Us to request a sample with full COA.

Contact Us

Ready to source high-purity berberine hydrochloride for your next product with Berberine HCL Powder? Reach out to our team at duke@hongdaherb.com.