Tildipirosin Powder: Innovation in Animal Health Care

Why Tildipirosin Is the Top Choice for Bacterial Infections in Livestock

What is Tildipirosin?
Tildipirosin Powder is a new semi-synthetic antibiotic of the sixteen-membered ring macrolide type specifically for animals. It is a derivative of tylosin. Pure tediloxin is a broad-spectrum animal antibacterial agent. The pathogenic bacteria of respiratory diseases in pigs, cattle and other animals or pets have good antibacterial activity, high utilization and low residue. High safety and other advantages.

 

So, what are the benefits of Tildipirosin, as a new animal-specific antibiotic?
The antibacterial properties of tilesin are similar to those of tylosin powder. It has a strong inhibitory effect on both Gram-positive bacteria and some Gram-negative bacteria. It has a strong inhibitory effect on Pasteurella multocida and Actinobacillus pleuropneumoniae in pigs and cattle. , Bordetella bronchiseptica, Haemophilus parasuis, Mannheimia hemolytica, Histophila somnifera, Mycoplasma, Spirochaete, Brucella, etc. all have inhibitory effects.
The antibacterial mechanism of tedirosin is the same as that of macrolide drugs such as tylosin. They can combine with the 50S subunit of the ribosome of sensitive bacteria to inhibit and prevent the synthesis of nucleoprotein peptide chains and bacterial proteins. Synthesis. Under different pH conditions, different charged forms are formed. The amount of charge is a key factor in destroying the solubility of bacterial lipids and penetrating the outer membrane of Gram-negative bacteria. Therefore, the antibacterial activity of tedirosin in vitro is greatly affected by pH. Under acidic conditions, the protonation of the amino group reduces the antibacterial activity of tedirosin; under alkaline conditions, it has higher antibacterial activity.

 

The therapeutic effect of Taidilosin on pig respiratory diseases:
Tildirosin bulk powder can be rapidly absorbed in pigs, accumulates at the site of respiratory tract infection, has a short peak time, a long elimination half-life, and is widely distributed, so it can fully treat respiratory disease infections.

 

What are the uses of Tildilosin?
1. The cure rate of tildirosin and florfenicol in treating pigs with respiratory system diseases. The cure rate of tedirosin is 86%, and the cure rate of florfenicol powder is 81%. Therefore, the cure rate of tedirosin is 86%. The cure rate of the powder was significantly higher than that of Pure Florfenicol Powder.
2. The cure rates of tildirosin and telamicin in treating pigs with respiratory system diseases. The cure rates of tedirosin and telamicin are similar, with cure rates of 93% and 92% respectively. Experimental It shows that both have good therapeutic effects on respiratory diseases.
3. Tildirosin can effectively treat diseases caused by Haemophilus parasuis infection, and has a good therapeutic effect on respiratory diseases caused by natural infection with Haemophilus parasuis and Actinobacillus pleuropneumoniae.

4. Ten days before heifers were artificially infected with Mannheimia hemolytica, the preventive therapeutic effect of tedirosin was significantly higher than that of telamicin powder. Tedirosin is used to treat infectious disease in sheep caused by spirochetal infection. It has obvious effects on dermatitis and respiratory diseases related to Mycoplasma bovis.
5. The cure rate and mortality rate of cattle with respiratory system diseases treated by pure tildirosin and telamicin. The cure rate of tedirosin is higher than that of telamicin, and the cure rates are 84.8% and 79.3% respectively. The effect of preventing and treating Haemophilus is also better than that of telamectin.

6. Tedirosin has a significant therapeutic effect on Bordetella bronchiseptica, with a cure rate of 70%, which is the same as that of teramectin.
7. Compare tedirosin bulk with telamycin in the treatment of early infection of pigs with Haemophilus paraparasanitis. Compared with other antibacterial drugs, the use of tedirosin injection in the treatment of Haemophilus parasuis The curative effect is significantly better.
8. Pure tediloxin can improve the respiratory syndrome of post-weaning piglets, significantly improve pig mortality, piglet elimination rate, weight gain and recurrence, and can effectively improve the growth efficiency and economic benefits of pigs.
9. Tildipirosin bulk can increase the weight gain of cattle by 13%, increase hip width, reduce the incidence of respiratory and intestinal diseases, improve the growth performance of cattle, and reduce the prevalence of respiratory diseases.

 

The difference between tedirosin and telamycin, tildirosin, and gamithromycin:
1. Gamimycin, a new product in the field of veterinary respiratory tract

Gamithromycin, a macrolide antibiotic, is mainly used to treat cattle infectious diseases caused by bacterial pathogens such as hemolytic Pasteurella, hemorrhagic septicaemia and histophila. It has the ability to absorb It has the advantages of rapidity, wide distribution in the body, low residue in the body, and high safety.
Applicable symptoms: Gamimycin powder is used to treat respiratory diseases (BRD) caused by Mannheimia hemolytica, Pasteurella and Histophila somnifera in meat-eating cattle and non-lactating cattle, and to control respiratory diseases caused by Mannheimia hemolyticus and Histophila somnifera. High risk of respiratory tract infection caused by Mycobacterium spp.
2. Veterinary drug tildipirosin, a new product in the respiratory tract field of veterinary drugs
Wholesale Tildipirosin powder, as a new type of macrolide animal-specific antibiotic, is mainly used in veterinary clinics to treat bovine respiratory tract infections caused by Mannheimia hemolytica, Pasteurella multocida and Haemophilus somnifera. and porcine respiratory tract infections caused by Actinobacter pleuropneumoniae, Pasteurella multocida, Borstella bronchiseptica, and Haemophilus parasuis.
3. Telamycin, a new product in the field of veterinary respiratory tract
Tulathromycin powder is a macrolide semi-synthetic antibiotic specially designed for animals. It is mainly used for respiratory diseases of pigs and cattle caused by Actinobacteria, Mycoplasma, Pasteurella and Haemophilus para. , has many advantages such as low dosage, low residue, high safety and animal-specific use.

 

How safe is Tidilosin?
Tildipirosin veterinary does not have any adverse effects on pigs, cattle, dogs, and lambs, but using 5 times the amount may cause damage to the heart, liver, and kidneys, mild itching, dyspnea, coughing, and other adverse reactions.
Tildipirosin soluble powder has strong antibacterial activity against pathogenic bacteria that cause respiratory diseases. It is suitable for the preventive treatment of respiratory diseases in pigs, cattle and sheep, and has wide uses in animal diseases.

 

Where can I buy Taidirosin?
Shaanxi Hongda is a specializing in the production of Tildipirosin powder factory. It has been engaged in the production of natural plant extract powders and the research and development of animal and veterinary drug raw materials for 30 years. It is equipped with professional veterinary drug production and R&D workshops to prepare various animal and pet products for customers. Raw materials only make a contribution to global animal health. If you want to promote animal health, you are welcome to inquire us by duke@hongdaherb.com.

 

Reference:

1、Priscila Rodrigues Peres ,Simone Ramos Prigol ,César Bernardo Gutiérrez Martín ,César Feronatod ,Miquel Collell Suriñach ,Luiz Carlos Kreutz ,Rafael Frandoloso.Tildipirosin: An effective antibiotic against Glaesserella parasuis from an in vitro analysis.

2、M. MENGE, M. ROSE, C. BOHLAND, E. ZSCHIESCHE, S. KILP, W. METZ, M. ALLAN, R. RÖPKE, M. NÜRNBERGER.Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle).

3、Lei Z, Liu Q, Yang B, Ahmed S, Cao J, He Q. The pharmacokinetic-pharmacodynamic modeling and cut-off values of tildipirosin against Haemophilus parasuis. Oncotarget. 2017 Dec 7;9(2):1673-1690. doi: 10.18632/oncotarget.23018. PMID: 29416722; PMCID: PMC5788590.