Premium Citicoline Sodium Powder for Cognitive Health Solutions | Pharmaceutical Grade Nootropic Ingredient

Shaanxi Hongda Phytochemistry stands as your trusted manufacturer and supplier of pharmaceutical-grade Citicoline Sodium Powder, delivering exceptional purity above 99% HPLC with complete traceability. Our state-of-the-art 20,000-square-meter plant produces 3,000 tonnes per year, supported by cGMP, FSSC22000, ISO22000 and FDA Certifications. We have over 20 years experience in the manufacturing of neurological ingredients and give extensive technical documentation, third-party testing results and customisable customisation services. Our strict quality control procedures, European and American warehouse availability, and specialised R&D assistance can help speed up your product development cycle and ensure your formulations are compliant with regulations in world markets.

Product Introduction

Citicoline Sodium (CAS 33818-15-4) is a neurological substance with high bioavailability which is required for the formation of phospholipids in the membranes of brain cells. It is a white crystalline powder that is highly soluble in water (>100 mg/mL). Citicoline Monosodium Salt Powder is often used in a variety of nootropic stacks, stroke recovery procedures and neuroprotective formulae. Our premium quality material maintains pH stability of 6.0-7.5 in aqueous solutions, avoiding degradation of multi-ingredient formulations and ensuring constant medicinal effectiveness of your finished products.

Supplement Citicoline Sodium 99% powder

Third Party Test Report

Quality Verification: Completed Our goods are rigorously tested by globally recognised labs like as SGS and Eurofins to provide you full transparency for your regulatory filings.

Pesticide Residue Testing: Multi-residue scan for the absence of more than 500 agricultural chemicals, in accordance to the EU rules (EC) No 396/2005 and US EPA guidelines for medicinal ingredients.

Heavy Metal Screening: Advanced atomic absorption spectrophotometry confirms lead <0.5ppm, arsenic <0.5ppm, cadmium <0.2ppm, and mercury <0.1ppm, meeting USP <232> heavy metals criteria.

Microbiological Safety Total plate count <1000 CFU/g Yeast & Mould <100 CFU/g E.coli, Salmonella and Staphylococcus aureus not detected as per USP <2021>.

laboratory

Specification

Item of Test	Limits of Test	Results of Test
Appearance	White crystalline or crystalline powder	Conform
Assay by HPLC	≥98%	99.85%
Identification	(1)A green colour is produced (2)The retention time of the principal peak in the chromatogram obtained with the test solution is identical with that of the principal peak in the chromatogram obtained with the reference solution (3)The infrared absorption spectrum is concordant with the standard spectrum. (4)The aqueous solution yields the reaction (1)characteristic of sodium salts.	Complies Complies Complies Complies
pH	6.0---7.5	6.9
Clarity, color of solution	Clear, colorless	Complies
Chloride	≤0.05%	Complies
Ammonium salt	≤0.05%	Complies
Iron salt	≤0.01%	Complies
Phosphate	≤0.1%	Complies
Related substances	5'-GMP≤0.3%	0.006%
	Single impurity ≤0.2%	0.006%
	Total Another Impurity≤0.7%	0.02%
Residual solvents	Limit of methanol≤0.3%	Undetected
	Limit of ethanol≤0.5%	Undetected
	Limit of acetone≤0.5%	Undetected
Loss on drying	≤6.0%	0.8%
Heavy Metals	≤5ppm	Complies
Arsenic salt	≤0.0001%	Complies
Endotoxin	<0.30EU/mg	Complies
Limit of microbe	Total bacterial count≤1000 CFU/g Yeast & Mold≤100 CFU/g E. Coli: Negative	< 10 CFU/g < 10 CFU/g Undetected

Conclusion

The product meets with the CP2020 standard.

Citicoline Sodium Powder Advantages

Increased Bioavailability: The sodium salt formulation boosts intestinal absorption by 35% quicker than free-base compounds, leading to a more rapid therapeutic onset and superior clinical results in cognitive enhancing applications.

Exceptional Stability Profile: Our state-of-the-art crystallisation method produces molecules that are thermally stable up to 180°C during tableting and encapsulation, ensuring no loss of potency throughout manufacture.

Pharmaceutical Grade Purity Multiple step chromatographic purification creates 99%+ purity with low levels of related compounds to minimise formulation interference and increase predictability in shelf-life for your final goods.

Broad Formulation Compatibility: The neutral pH and high compressibility make it easy to include into tablets, capsules, oral solutions and parenteral formulations without considerable excipient optimisation.

Citicoline Sodium Powder Uses

Cognitive Health Supplements: Create quality nootropic blends that support memory, concentration, and mental performance as you age, with scientifically effective doses of 250-1000mg/day.

Stroke Recovery Protocols: Establish hospital-grade treatment options for neurological recovery after ischaemia, using neuroprotective mechanisms to improve cerebral blood flow and neurotransmitter production.

Ophthalmological Preparations : Develop specific eye health formulations for glaucoma and age-related macular degeneration by improving retinal blood circulation and photoreceptor protection.

Sports Nutrition Products: Design performance-boosting supplements for athletes looking to increase response speed, maintain focus throughout competition, and expedite neurological recovery post-workout.

Use Of Citicoline

Manufacturing Process

Step 1 - Raw Material Verification: All incoming cytidine and choline precursors are rigorously tested by HPLC to validate identification and purity criteria and provide full batch traceability to assure consistent starting material quality.

Step 2 - Enzymatic synthesis: Controlled biocatalytic phosphorylation processes are carried out in temperature-controlled reactors at 25 °C, resulting in CDP-choline intermediates with >95% conversion and low side-product generation.

Step 3 - Formation of Sodium Salt Accurate stoichiometric addition of pharmaceutical-grade sodium hydroxide produces stable monosodium salt complexes with the drug and enhances solubility qualities while retaining chemical integrity via crystallisation.

Step 4 - Multi-Stage Purification: Unreacted precursors, residual enzymes and organic contaminants are removed in a multi-stage process of recrystallisation and membrane filtering, to pharmaceutical grade purity that exceeds international pharmacopoeia regulations.

Step 5 - Spray Drying & Milling: We use state-of-the-art spray-drying technology to provide consistent particle distributions in the 80-200 mesh range that provide great flowability and content uniformity for further processing applications.

Step 6 – Quality Assurance Release – Finished goods undergo rigorous testing such as assay confirmation, heavy metal testing, microbiological testing and stability testing before to release to warehouse and issuing of certificates.

Why Choose Us

Shaanxi Hongda Phytochemistry provides an unrivalled value proposition, with vertical integration from raw material cultivation to final product delivery. We bring 23 years of industry experience to the table, merging professor-level R&D know-how with automated production processes to guarantee batch-to-batch consistency. We are committed to quality excellence and have many international certifications like cGMP, FSSC22000 and ORGANIC (EU/NOP). Strategic warehousing throughout Europe and America ensures speedy order processing, and our dedicated customer care staff offers real-time technical advice. Choosing us means working with a provider that knows your formulation issues and regulatory needs, providing you with a consistent supply of Citicoline Sodium Powder to boost your competitive advantage.

our certifications

OEM/ODM Service

Custom Formulation Development: Our 20-person R&D team works together to develop custom blends, appropriate dosage forms and synergistic ingredient combinations that fit your target market needs and regulatory environment.

Versatile Production Capabilities All-in-one solutions like as tablets, hard/soft capsules, sachets, and ready-to-mix powders created in our 100,000-level purification facilities under stringent cGMP regulations.

Private Labelling Services Complete branding services including package design, compilation of regulatory documents, stability studies and nutrition labelling in accordance with FDA, EU and regional authority requirements.

Package Technical Documentation: Get full DMF (Drug Master File) preparation help, analytical method transfer procedures and continuous technical support for seamless regulatory approvals in target markets.

OEM service

FAQ

Q: What is your minimum order quantity?

A: We can handle from 1kg samples up to commercial multi-ton amounts and have various packing solutions.

Q: Do you have any regulatory backing documents?

A: Yes, we provide full COA, third party test results, allergy statements, BSE/TSE certifications and GMO free declarations with all shipments.

Q: What is your usual lead time?

A: Stock goods are sent within 3-7 business days; bespoke formulas are 15-20 days based on the requirements.

Q: Do you offer product samples for testing?

A: Complimentary 20-100g samples are available for qualified manufacturers conducting formulation trials.

Q: Which quality standards does your product meet?

A: Our material conforms to USP, European Pharmacopoeia, Japanese Pharmacopoeia, and Chinese Pharmacopoeia monograph requirements.

Contact Us

Ready to elevate your neurological health formulations with premium Citicoline Sodium Powder? Contact our international sales team at duke@hongdaherb.com to begin your partnership with China's leading phytochemical manufacturer.