Levodopa Powder

Premium Levodopa Powder Manufacturer & Supplier | Shaanxi Hongda Phytochemistry

Shaanxi Hongda Phytochemistry Co., Ltd. is a reputed manufacturer and supplier of pharmaceutical grade Levodopa Powder, providing unparalleled quality to the global market since 2001. Being a top raw material plant focusing on natural plant extracts and Active Pharmaceutical Ingredients (API) provides you with exclusive benefits that directly cater to your formulation requirements. Our advanced intelligent extraction equipment and SGS standardised laboratory are located in a 20,000-square-meter state-of-the-art facility and staffed by professor level R&D people. Certified cGMP, FSSC22000, ISO22000, HALAL, KOSHER, ORGANIC, we make sure that every batch fulfils the world pharmacopeial requirements.

Product Introduction

Our flagship product is 3,4-Dihydroxy-L-phenylalanine (or L-DOPA), a metabolic precursor of dopamine, which has remarkable penetrative properties across the blood brain barrier. Mucuna Pruriens Mucuna Pruriens is purified to pharmaceutical quality by modern synthesis and extraction procedures. This off white crystalline powder is HPLC fingerprinting for enantiomeric purity and identification verification is performed for each production batch. The powder has a specific optical rotation of -160° to -167° and melting point of 276-278°C, providing consistent performance in your compositions.

Third-Party Test Report

Enantiomeric Purity Verification: Our third-party laboratories conduct chiral HPLC analysis confirming zero D-DOPA contamination, with specific optical rotation strictly maintained within -160° to -167° range. This eliminates pharmacologically inactive isomers that contribute to toxicity concerns.

Heavy Metals & Elemental Analysis: ICP-MS testing by SGS and Eurofins validates Lead, Arsenic, Cadmium, and Mercury levels remain below 10 ppm total, meeting ICH Q3C guidelines for long-term chronic dosing safety.

Residual Solvent Screening: Gas chromatography confirms Class 1, 2, and 3 solvents (Methanol, Acetone, Ethyl Acetate) remain below detection limits, ensuring compliance with international pharmaceutical standards.

Levodopa Powder Specification

Levodopa Powder Advantages

Enhanced Bioavailability: Our micronised crystallisation process delivers particle sizes (D90 < 20μm) that promote quick dissolving within gastric fluids and improved absorption via the duodenal large neutral amino acid transporter (LAT1).

Exceptional Stability Profile: Sophisticated manufacturing controls inhibit oxidative degradation and discolouration, improving the shelf life of your finished formulations without compromising potency during storage conditions.

Ultra-Low Impurity Content: Related compounds such as L-Tyrosine, 3-Methoxytyrosine and Veratric Acid are strictly limited to maintain total impurities below 1.0%, minimising toxicological concerns and side effect profiles in clinical applications.

Levodopa Powder Application

Treatment of Parkinson's Disease: The main goal of treatment is to counteract the loss of dopamine in the substantia nigra, with the ability to cross the blood brain barrier to re-establish regulation of motor function and diminish symptoms of bradykinesia, stiffness and tremor.

Dopamine-Responsive Dystonia Treatment: Offers excellent treatment for inherited movement disorders due to malfunction in the dopamine pathway that produces persistent muscle spasms and aberrant posturing in both paediatric and adult populations.

Nutraceutical Formulations: Used in dietary supplements designed to promote cognitive enhancement, mood support, and neuroprotection in combination with natural decarboxylase inhibitors derived from botanicals.

Production Process

Step 1 - Raw Material Selection: We carefully select premium Mucuna Pruriens seeds from our certified organic planting bases or pharmaceutical-grade synthetic precursors, followed by professional agronomist verification. Result: Only raw materials meeting pharmacopeial heavy metal and pesticide residue standards advance to extraction.

Step 2 - Accurate Extraction: We use modern solvent extraction technology in our 100,000-level purification workshops, with temperature-controlled processing to protect molecular integrity. Extraction of the maximum yield without thermal degradation of the active ingredient.

Step 3 - Multi-Stage Purification: Chromatographic separation in series removes related compounds and contaminants with particular resin columns and crystallisation methods. Achieved ≥99% purity with enantiomeric specificity determined by chiral HPLC.

Step 4 - Controlled Crystallisation: The controlled cooling speeds and precise pH adjustment result in homogenous crystal shape with excellent particle size distribution. Result: Uniform flowability and dissolving characteristics suitable for pharmaceutical formulation.

Step 5 - Micronization & Drying: The moisture content is reduced to ≤1.0% by advanced fluid bed drying, followed by jet milling to accomplish the D90 < 20μm particle standard. Enhanced bioavailability and formulation compatibility.

Why Choose Us?

Shaanxi Hongda Phytochemistry has 23 years of manufacturing excellence with a production capacity of up to 3,000 tonnes per year on over 10 sophisticated production lines. Our warehouse is 3000 sqm and diverse and has considerable inventory to ensure 3-7 working days delivery schedules to keep your supply chain uninterrupted. On top of that, you benefit from an integrated quality management system, where each production process is monitored in real-time by more than 20 professor level quality control professionals with HPLC, GC, ICP-MS and spectrophotometric equipment. The 3 recognised planting bases allow us to trace from seed to powder. And being a national high-tech enterprise means we keep innovating in the extraction technique.

OEM / ODM Support

Custom Formulation Development: Our team of professors in the R&D department collaborates with you to create customised blends that mix Levodopa Powder with other complementary compounds such as Carbidopa, Green Tea Extract, or vitamin cofactors according to your target market criteria.

Flexible Dosage Form Solutions: We develop unique soft capsules, hard capsules, instant release tablets, sustained release matrices, and premixed powders to meet your clinical efficacy and patient compliance goals.

Packaging Customisation Services: Select from pharmaceutical-grade aluminium foil bags, HDPE bottles with desiccant canisters, or bulk fibre drums, all of which can be customised with your private label branding and regulatory compliance information.

FAQ

Q: What is the minimum quantity of order for this product?

A: Our normal MOQ is one drum (25kg net weight) but we offer samples of 20-100g for first qualification test.

Q: How do you ensure the absence of D-DOPA contamination?

A. Each batch is subjected to chiral HPLC analysis and polarimetry testing, with optical rotation verification showing enantiomeric purity between -160° to -167°.

Q: What is the shelf life if stored properly?

A: Our substance has a shelf life of 24 months from the date of manufacture when stored in sealed containers, out of light and moisture, at controlled room temperature.

Contact Us

Ready to secure a reliable supply of pharmaceutical-grade Levodopa Powder backed by comprehensive quality assurance?

Email: duke@hongdaherb.com