Cyanocobalamin Vitamin B12 Powder

Cyanocobalamin Vitamin B12 Powder — 98% Purity Crystalline Supplement Grade for Pharma & Nutrition

Pharmaceutical quality Cyanocobalamin Vitamin B12 Powder 96.0%-100.5% (on an anhydrous basis) validated by HPLC from Shaanxi Hongda Phytochemistry Co., Ltd. This synthetic vitamer is available as a dark-red crystalline powder (CAS: 68-19-9) and fits the specifications of USP, EP, BP and JP. It has better resistance to oxidation than Methylcobalamin, making it the ideal active ingredient for solid dosage forms, fortification of functional foods and animal nutrition premixes. Hongda services customers across Europe, North America and Asia with an annual output capacity of 3,000 tons, 3-7 working day delivery and certification includes HALAL, KOSHER, ISO9001, ISO22000, BRC and ORGANIC.

Product Introduction

Cyanocobalamin Vitamin B12 Powder is the commercially used synthetic form of the Vitamin B12 family. Chemically the form of B12 is called Coα-[α-(5,6-dimethylbenzimidazolyl)]-Coβ-cyanocobamide. It has a cobalt ion at the centre of a corrin ring. It has a cyanide ligand that gives it its own stability advantage.

This chemical is critical for cell metabolism, DNA production and maintenance of myelin sheaths in the neurological system. The body then transforms it enzymatically into active coenzyme forms, including Methylcobalamin and Adenosylcobalamin.

Cyanocobalamin is stable against photolysis and oxidation under normal circumstances of storage and processing. This is a clear advantage to formulators of long shelf-life goods versus the naturally occurring cobalamin analogues.

Product specification

Third-Party Test Report

Shaanxi Hongda cooperates with the world’s leading testing agencies including SGS, Eurofins etc. to ensure the third party test for the quality data of each batch.

Each batch is checked for pesticide residues, heavy metals, microbiological limits and nutritional labelling. HPLC analysis also particularly screens for pseudo-cobalamin (a fermentation counterpart that is physiologically inactive) to prevent false indications of potency, a quality step that many vendors do not perform.

A comprehensive third party test report is available for viewing prior to placing your order. Batch traceability records are maintained for all products shipped.

Cyanocobalamin Vitamin B12 Powder Advantages

Exceptional Oxidation Resistance

The cobalamin structure is protected against oxidative degradation and thermal stress by the cyanide ligand. This makes it much more stable than Methylcobalamin in aqueous solutions where exposure to light and oxygen usually necessitates expensive protection.

Ready for Formulation Stability

It retains activity after pasteurisation, extrusion and high-speed tablet compression, processing conditions in which other B-vitamin forms generally lose activity.

Transparency applications: colour considerations

Even at low quantities the strong red pigment can add a pink tint to clear liquids or white tablet coatings. Your R&D Team should incorporate color-matching and titration experiments in formulation.

Pharmacopoeia Compliance

Conforms to USP, EP, BP, JP and FCC standards – ready for pharmaceutical, nutraceutical and food-grade applications without further qualification stages.

Suitable Sourcing for Vegans

The material supports confirmed Vegan/Vegetarian product claims when generated with non-animal fermentation substrates (Pseudomonas denitrificans or Propionibacterium shermanii) and using plant-based carriers such as Mannitol or Maltodextrin.

COA (Certificate of Analysis)

Each shipment of our Vitamin B12 powder includes a comprehensive Certificate of Analysis (COA) containing the following validated data points:

• Identification: UV spectrophotometric confirmation at absorption maxima 278 nm, 361 nm and 550 nm

· Assay (HPLC): Not less than on an anhydrous basis

· Related Substances: Limits are established for hydroxycobalamin and degradation product

· Residual Solvents: GC testing to ICH Q3C limits (including acetone from crystallisation)

· Heavy Metals: ICP-MS testing

· Microbiology: TPC, Salmonella, E. coli and Pseudomonas aeruginosa are tested and documented

If you want to purchase, you can email duke@hongdaherb.com and ask for a sample COA.

Production Process

Shaanxi Hongda is a GMP manufacturer of Cyanocobalamin via controlled microbial fermentation with extraction, crystallisation and drying.

The process flow is Fermentation → Extraction → Purification → Crystallisation (solvent controlled) → Drying → QC Testing → Packaging

All crystallisation solvents are eliminated to ICH Q3C limits as validated by GC analysis. Consistent batch-to-batch quality is ensured by a 100,000-level purification workshop and 10+ advanced production lines with an annual output of 3,000 tons.

Why Choose Us?

· Manufacturer founded in 2001, with a 20,000m² factory and 100,000 level purifying workshops

· Laboratory in-house to SGS standard with HPLC, GC, UV and atomic absorption equipment

• SGS and Eurofins third party verification for each production lot

· Compliant with many standards: HALAL, KOSHER, ISO9001, ISO22000, FSSC22000, cGMP, BRC, ORGANIC (EU & NOP)

• 3,000 tons per year capacity with 3-7 working days supply and specialised stocking area (Area E) for vitamin

• One-to-one service: Dedicated sales and technical support from enquiry to after-sales service

OEM / ODM Support

Shaanxi Hongda enables comprehensive OEM and ODM customisation for B2B buyers. You may request:

· Custom specifications: Carrier option (Mannitol, Maltodextrin, etc.) for trituration mixes

· Custom packaging: Double layer PE bags in fibre drums, or customer branded labelling

· Special dose forms: Premixed powder, hard capsule, tablet, softgel

• Documentation tailored to your needs: Specification papers, safety data sheets, country-specific regulatory support

Minimum order quantities and custom formulation lead times are confirmed on enquiry. Please contact the team directly to discuss the scope of your project.

Cyanocobalamin Vitamin B12 Powder Application

Pharmaceutical Solid Dosage Forms

For direct compression in tablet and capsule manufacture. Because of the high potency of this medication, segregation in blends can occur and facilitate content homogeneity. Thus, a trituration (dilution) form is usually used to provide the dosing strength of this medication (e.g., 0.1% or 1% on a carrier).

Functional Food and Beverage Enrichment

Added to energy drinks, morning cereals and plant milk replacements. It is thermally stable, surviving pasteurisation and extrusion procedures. Protect the formulation from exposure to high intensity UV radiation for ready to drink beverages.

Premixes for Animal Nutrition

Common active ingredient in premixes for chicken and pig feeds to prevent anaemia and growth retardation. The material is resistant to contact with minerals and changes in humidity typical for the bulk feed silo environment.

FAQ

Q1: How do Cyanocobalamin and Methylcobalamin perform in liquid formulations in terms of stability?

A: Cyanocobalamin is much more stable in water. Methylcobalamin Nitrogen sparging, overages and amber glass protection. Cyanocobalamin is more stable under normal storage settings.

Q2: Is it suitable for vegan labelled products?

A: Yes – if the fermentation substrate is non animal based and the carrier is plant derived (Mannitol or Maltodextrin). Please get our vegan declaration document to verify compliance.

Q3: What are the storage conditions?

A: Store in tight, light-resistant containers in low humidity. Thermal stability is good however photolysis takes place on direct light exposure . Hygroscopicity: Avoid open storage in humid areas.

Q4: How do you check for pseudo-cobalamin in your QC?

A: Specific HPLC procedures are used to separate and measure pseudo-cobalamin. This assures your potency claims are correct by eliminating the counting of physiologically inactive counterparts in the experiment.

Q5: What’s the standard packing for a regular B2B order?

A: 25 Kg per fibre drum with double layer PE inner bag is the standard package. Sample packing in thickened PE bags in aluminium foil bags (20–100 g). Custom packaging available.

Q6: What USP or other pharmacopeial criteria does your product meet?

A: The item complies with the monographs of USP, EP, BP, JP and FCC. We can provide COA data referencing these criteria for each batch upon request.

Contact Us

Ready to source verified Cyanocobalamin Vitamin B12 Powder for your formulation? Email duke@hongdaherb.com to request a COA, sample, or custom quote today.