Acetyl Hexapeptide-8 Powder

Acetyl Hexapeptide-8 Powder (Argireline) — High-Purity Anti-Wrinkle Peptide for Professional Cosmetic Formulation

Acetyl Hexapeptide-8 Powder from Shaanxi Hongda Phytochemistry Co., Ltd. is ≥98% pure (HPLC-verified) and is used by cosmetic formulators in Europe, North America, Asia, Vietnam, and Switzerland. Hongda has been making peptides for over 20 years, has 100,000-level purification labs, and makes 3,000 tons of them every year. They offer a stable, high-potency raw material that is certified by cGMP, Kosher, Halal, ISO9001, ISO22000, BRC, and FDA. Each batch meets strict international quality standards, including being able to track the raw materials and being tested by third parties like SGS and Eurofins.

Product Introduction

Acetyl Hexapeptide-8 Powder (trade name Argireline) is a synthetic hexapeptide with the amino acid sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂. This is made from the N terminal domain of the SNAP-25 protein.

Its mechanism is by competitive inhibition. The peptide mimics SNAP-25 to destabilise the SNARE complex, hence preventing the release of acetylcholine vesicles at the neuromuscular junction. This causes a decrease in muscular activity and significantly reduces dynamic wrinkles such as crow’s feet, glabella lines and furrows on the forehead.

This substance in powder form minimises the dangers of hydrolysis of pre-diluted aqueous solutions. Shelf-life: Up to 24 months when stored at 2-8°C, with efficacy retained far more reliably than with liquid format alternatives.

Third-Party Test Reports

All production batches are subjected to stringent quality checks, both in-house and by accredited external laboratories.

In-house tests include: appearance, particle size, bulk density, purity (HPLC), moisture (Karl Fischer), specific rotation and content of heavy metals.

SGS and Eurofins provide third-party verification, including testing for pesticide residue and providing documentation on the natural report, microbiological limits and nutrition labelling where relevant.

All tests are traceable by batch number and comprehensive paperwork including CoA, MSDS and 3rd party reports will be available to B2B buyers on request.

Acetyl Hexapeptide-8 Powder Advantages

High Purity, Low Inclusion Rate

This peptide is biologically active at 0.05%-0.1% inclusion and >=98.0% pure (HPLC). You achieve powerful efficacy without compromising your formulation texture or cost structure.

More Stability than Liquid Formats

The lyophilized powder form protects from hydrolysis breakdown during storage and shipping. Shelf life is 24 months at 2-8°C – a big advantage over pre-dissolved solutions.

Compatible with a wide range of formulations

This peptide is water soluble (>1g/mL) and stable in a pH range of 3.0-8.0 which makes it easy to incorporate into serums, eye creams and emulsions. It is effective in formulations with high level of hyaluronic acid, emulsifiers and common preservatives.

Safety Profile Non-invasive

No persistent muscle paralysis or immune response risk – problems with injectable Botulinum Toxin A. Suitable for delicate skin applications, heavy metals are under 10 ppm.

Adjustable concentration

Unlike industry solutions of fixed 500 ppm, the powder allows reconstitution at any concentration required for your recipe. This allows your R&D team full flexibility.

COA

Acetyl Hexapeptide-8 Powder Application

High-Performance Anti-Aging Serums

Active substance used targeting expression lines - wrinkles on the forehead, crow's feet and glabella folds. Does not lose its activity and works well with humectants such as hyaluronic acid.

Post Procedural Skin Care (Medical Aesthetic)

Clinics are using topical preparations containing this peptide to increase the time between Botox treatments. The peptide adds a muscle-relaxing impact that is complementary to stabilise and maintain the outcomes.

Eye Contour Details

Its non-irritating nature also makes it acceptable for high-end eye creams, where it provides a perceptible lifting effect without the vascular dangers of more aggressive actives. It is stable in the presence of a variety of emulsifiers and preservatives commonly used in eye area formulations.

Production Process

Shaanxi Hongda generates this peptide utilising solid-phase peptide synthesis (SPPS) under strict clean-room conditions in a 100,000-level purification workshop.

Each batch is: source material verification, synthesis, purification, lyophilization, quality inspection, packing. All procedures are done following stringent SOP guidelines in compliance with cGMP requirements.

Each batch is evaluated for purity (HPLC), specific rotation, moisture, heavy metals and microbiological restrictions before to release. Only batches that are in full specification are approved for shipping.

Our Factory

Our Certifications

Our Exhibitions

Delivery Methods

OEM / ODM Support

Shaanxi Hongda also provides custom formulation development for B2B customers seeking final products that use this peptide.

Available formats include: serums, eye-cream, soft capsules, hard capsules, tablets, premixed powders. We can provide custom Packaging, label design and private branding to suit the needs of your market.

Your project contact will help you through from concept to final production with full documentation at every step.

Why Choose Us

· Established manufacturing in 2001, with 20,000 m² facilities and 3,000-ton yearly production

· Certifications: cGMP, ISO9001, ISO22000, FSSC22000, Kosher, Halal, BRC, FDA, Organic (EU & NOP)

• SGS-standard laboratory with 20+ R&D and QC personnel on-site

· Third-party testing of all product categories by SGS and Eurofins

• Delivery: 3–7 working days with sufficient stock in warehouse

· OEM/ODM customisation possible with flexible numbers

FAQ

Q1: What is the advised dosage of this peptide in final products?

A: Approximately 0.05-0.1% of the pure peptide. This concentration allows for efficient SNARE-complex inhibition at ≥98% purity without overloading the formulation.

Q2. How should the product be stored?

Store in a tightly closed container at 2-8°C, away from direct light and moisture. Under these conditions the product is stable for 24 months. Do not keep for prolonged periods at temperatures above 25°C.

Q3: Would this peptide work in a hyaluronic acid and vitamin C formulation?

Q: Yeah. It is stable in the pH range of 3.0-8.0 and is highly water soluble. It is compatible with most water phase actives including HA. Lower pH vitamin C formulations are generally within its stable range.

Q4: What paperwork do you provide for customs and regulatory compliance?

A: Yes, we can provide CoA, MSDS, HPLC test report, third party test reports (SGS/Eurofins) and copies of certifications (cGMP, Halal, Kosher etc). You can arrange further documentation as per your import requirement.

Q5. What is the lowest order quantity?

A: The normal packing is 25kg/drum. Samples for testing can be supplied in weights from 20 g to 100 g. Please Contact Us directly for MOQ data by project amount.

Q6: How is this different from a pre-diluted solution of Argireline (ex: 500 ppm)?

A. You can change the concentration using the powder. The pre-diluted solutions are standardised to ~0.05% peptide, but the powder provides you the flexibility to manufacture at any level your product requires – and without additional solvents or preservatives that may interfere with your recipe.

Contact Us

Ready to request a sample or discuss your formulation needs with Acetyl Hexapeptide-8 Powder? Reach our team at duke@hongdaherb.com.