Hesperidin Extract

Hesperidin Extract — Citrus Bioflavonoid Powder | 95% HPLC Purity for Pharma & Nutraceutical Formulations

Shaanxi Hongda Phytochemistry Co., Ltd. supplies pharmaceutical grade Hesperidin Extract from Citrus aurantium L. standardised to 95% purity by HPLC. Hongda, with 20,000 m2 of production facilities, 3,000-ton annual output and Kosher, Halal, cGMP, ISO9001 and FSSC22000 Certifications, offers batch consistent flavanone glycoside material (C28H34O15) with full traceability. Before leaving, each batch is tested in-house for HPLC, heavy metal, pesticide residue and microbial contamination. Reliable supply for supplement, pharmaceutical and cosmetic applications. Packaging 25 kg/drum. Delivery 3-7 working days.

Product Introduction

Our product is a naturally occurring flavanone glycoside extracted from the epicarp and mesocarp of immature Citrus aurantium (bitter orange). Hesperidin is the active molecule, where the aglycone Hesperetin is linked to the disaccharide Rutinose, a structure with antioxidant and venotonic activity.

This extract is 95% pure by HPLC and addresses the active content variation often seen in generic citrus bioflavonoid complexes. It appears as a light yellow to brownish-gray fine powder and has CAS No. 520-26-3. Raw material is obtained from young, immature fruit to maintain optimal efficacy as hesperidin concentration declines rapidly as citrus fruit ripens.

This material is also the immediate precursor for Diosmin synthesis and Methyl Hesperidin production, so it is a key input for pharmaceutical vascular health treatments.

Product Specification

Third-Party Testing & Quality Assurance

Every batch undergoes testing at Hongda’s SGS-standardized laboratory before leaving the facility. Tests include HPLC purity, UV identification at 284 nm, moisture, ash, bulk density and particle size distribution.

In an effort to comply with safety requirements we implement the pesticide residue screening recommendations of EC 396/2005. This is especially important due to the citrus origin. The limitations for heavy metals are Pb < 3 ppm, As < 1 ppm. Methanol based extraction, residual solvents are regulated to fulfil ICH Q3C guidelines (< 3000 ppm).

Upon request, third-party verification is offered through SGS and Eurofins for pesticide residues, nutrition labelling, natural source confirmation, and particular optical rotation.

Key Advantages

Consistent HPLC Purity at 95%

HPLC quantification separates the Hesperidin from Naringin and Neohesperidin impurities – a typical UV approach cannot do this successfully. You get the real active content count, not an inflated number.

Solid-Dose Thermal Stability Manufacturing

It melts between 250 °C and 262 °C and is tabletable at high compression without deterioration, making it appropriate for pharmaceutical or supplement applications.

Available in Micronized Grade

Poor intestinal absorption of standard crystalline Hesperidin is due to its low water solubility. Micronization to D90< 10 µm enhances the dissolving surface area and bioavailability for MPFF grade medicinal applications.

Traceable source of raw materials

Hongda has its own planting bases for Citrus aurantium and traditional Chinese medicinal herb, and is managed by expert agronomists. Controlling the timing of harvest to catch the peak concentration of hesperidin in the immature fruit.

Application Areas

Pharmaceutical Vascular Treatments

Diosmin is primarily made from Hesperidin Extract as its basic material. One conventional pharmaceutical formulation is a micronized purified flavonoid fraction (MPFF), including a mixture of 90% Diosmin and 10% Hesperidin, for the treatment of chronic venous insufficiency, haemorrhoids and varicose veins.

Cosmeceutical Preparations

It enhances cutaneous microcirculation and minimises under-eye dark circles in topical and oral beauty products. It is an ideal ingredient for brightening serums due to its tyrosinase inhibitory effect. For topical application, liposomal encapsulation is suggested to bypass the hydrophilic barrier at the stratum corneum.

Sports Nutrition & Metabolic Assistance

The chemical has insulin-sensitizing effects and antioxidant protection against exercise-induced oxidative stress. It is compatible with caffeine and probiotic ferments for use in metabolic support formulations and can survive standard tabletting compression.

Clear Drink Applications

Hesperidin standard precipitates in acid drinks. Alpha-Glucosyl Hesperidin (enzymatically modified) or Hesperidin Methyl Chalcone is water soluble for liquid formats while keeping bioactivity.

Why Choose Shaanxi Hongda Phytochemistry?

· Manufacturer since 2001, 20,000 m2 plant, 3,000ton/year capacity

· In-house SGS standard laboratory with HPLC, GC, UV and atomic absorption equipment

· Staff includes more than 20 professor-level R&D and QC people

· Certifications: cGMP, FSSC22000, ISO9001, ISO22000, Kosher, Halal, BRC, FDA, Organic (EU & NOP)

• 3-7 working days shipping time, typical package 25 kg/drum

• OEM/ODM customisation, comprehensive documentation support

Production Process

The Hongda extraction process begins with immature Citrus aurantium peel acquired from regulated cultivation sites. The process includes: raw material inspection, alkaline extraction, acid precipitation, filtration, washing, drying, micronization (optional), sieving, QC testing and packaging.

The 100,000-level purification workshop is used for controlling airborne pollution during drying and milling. Solvent use is kept to a minimum and residues are checked against ICH Q3C limits before release. Full traceability records of each production batch from raw material harvest to completed product.

OEM / ODM Support

Hongda can tailor specifications to your end product demands. Available in powder, hard capsule, soft capsule, tablet and premixed blend versions. Purity grades, particle size grades and carrier materials can be customised to your formula requirements.

Private-label packaging assistance. We can manufacture your logo, label design and packaging format at the plant. Your account manager will discuss minimum order quantities and lead times with you on a one-to-one basis.

Our Exhibition

FAQ

Q1: What is the difference between Hesperidin and Hesperetin?

A: Hesperidin is the glycoside form – Hesperetin with the sugar Rutinose attached. Hesperetin (the aglycone) is more potent but also much more costly. The B2B Industry Standard for Affordable Formulations with Stability Needs.

Q2: Why HPLC purity is more important than UV purity?

A: UV techniques are incapable of separating Naringin, Hesperidin from structurally related chemicals such as giving inflated results. Pharmaceutical applications require HPLC for precise and interference free measurement.

Q3: What causes colour difference between batches?

A: Light variation from off-white to tan is common and depends on the harvesting season of the Citrus aurantium and drying conditions. Darkening can suggest oxidation or too much heat during crystallisation, therefore always request a fresh COA.

Q4: How to drink product – Clear Drink?

A: The standard material is not suited for acidic clear beverages, precipitation will occur. Ask for Hesperidin Methyl Chalcone or Alpha-Glucosyl Hesperidin for water-soluble liquid applications.

Q5: Do all applications need micronized grade?

A: No. Micronized grade (D90 < 10 μm) is approved for medicinal MPFF tablets when clinical bioavailability is established. Most dietary supplement capsules and topical cosmetic applications require only standard powder grade.

Q6: What documentation can be provided prior to purchase?

A: Hongda can offer COA, MSDS, specification sheet and third-party test results (SGS/Eurofins) upon request. All shipments come with certificates of origin and customs paperwork.

Contact Us

Ready to source pharmaceutical-grade citrus bioflavonoid material with Hesperidin Extract? Email duke@hongdaherb.com for samples, pricing, or technical documentation.