Andrographis Extract Andrographolide

Andrographis Extract Andrographolide - Premium Natural Plant Extract Manufacturer

Shaanxi Hongda Phytochemistry Co., Ltd. is a reputed manufacturer and supplier of premium Andrographis Extract Andrographolide. Since 2001 we are specialists in manufacturing standardized plant extracts meeting international pharmaceutical and nutraceutical requirements. Our state-of-the-art facility is a 20,000 square meter facility with 100,000-level purification operations maintaining the same bioactive content and purity of the product in each batch. Our strategy of vertical integration, from organic planting bases to state-of-the-art extraction technologies, gives us the edge and guarantees full traceability and quality assurance for you. We have Certifications like HALAL, KOSHER. cGMP, FSSC22000, ISO9001, ISO22000. We produce pharmaceutical grade extracts which answer the main problem in the industry, the batch to batch uniformity. Whether you are formulating immune supplements, anti-viral medications or liver health products we provide Andrographolide extracts from 10% to 98% purity exactly matched to your formulation requirements.

Product Introduction

The product is a standardized bioactive ingredient from aerial portions of Andrographis paniculata widely known as “King of Bitters”. It is a labdane diterpenoid lactone, and a potent natural pharmaceutical intermediate with immune-modulating and anti-inflammatory effects. Our extraction procedure concentrates the active ingredient to specifications from 10% to 98% Andrographolide content and removes the variability of crude herbal material. The powder form (white to off white) can be easily incorporated into tablet, capsule and liquid forms. This chemical with the molecular formula C20H30O5 and CAS number 5508-58-7 delivers proven therapeutic consistency that meets USP and CP monograph standards for global pharmaceutical uses.

Third-Party Test Reports

Independent Validation: All our product batches undergo rigorous testing by internationally recognized third-party laboratories including SGS and Eurofins, ensuring unbiased quality verification that meets your regulatory requirements.

Pesticide Residue Analysis: Multi-residue screening tests confirm compliance with EU and US organic standards, with detection limits below regulatory thresholds for over 500 pesticide compounds, protecting your brand from contamination risks.

Microbiological Safety Verification: Third-party microbiological testing validates Total Plate Count below 1,000 cfu/g with confirmed absence of Salmonella, E. coli, Staphylococcus aureus, and pathogenic organisms, ensuring consumer safety.

Heavy Metal Screening: ICP-MS analysis by accredited labs confirms our extracts meet strict limits for Lead (Pb < 3ppm), Arsenic (As < 1ppm), Cadmium (Cd < 1ppm), and Mercury (Hg < 0.1ppm), critical for export compliance.

Solvent Residue Testing: GC analysis verifies residual solvents remain within ICH Q3C guidelines, with Ethanol below 5000 ppm and Methanol below 3000 ppm, meeting pharmaceutical safety standards.

Certificate of Analysis (COA)

Andrographis Extract Andrographolide Advantages

Pharmaceutical-Grade Consistency: Our advanced HPLC-guided extraction ensures each batch maintains precise Andrographolide content within ±2% tolerance, eliminating formulation uncertainty and enabling reliable therapeutic dosing for your pharmaceutical preparations.

Enhanced Bioavailability Technology: Through proprietary micronization and solid dispersion processing, we've improved water dispersibility by 300% compared to standard extracts, addressing the inherent low solubility challenge that compromises absorption rates.

Superior Thermal Stability: Our Andrographis Extract Andrographolide withstands processing temperatures up to 85°C without degradation, making it ideal for tableting compression, encapsulation hot-melt processes, and veterinary feed pelleting applications.

Reduced Bitterness Profile: Advanced purification removes excessive bitter compounds while preserving bioactive potency, simplifying taste-masking requirements and reducing formulation costs for consumer-friendly supplement products.

Certified Organic Sourcing: Cultivated in our controlled planting bases with GAP compliance, our raw materials contain no synthetic pesticides or fertilizers, meeting USDA Organic and EU Organic certification standards for premium natural product positioning.

Andrographis Extract Andrographolide Applications

Pharmaceutical API Development: Utilized as the Active Pharmaceutical Ingredient in prescription medications targeting acute upper respiratory tract infections, pharyngitis, and bacterial dysentery, where its NF-κB inhibition mechanism reduces inflammatory cytokine production.

Immune Support Supplements: Formulated into seasonal wellness capsules and tablets at 10-50% concentrations, often synergized with Vitamin C, Zinc, and Echinacea for comprehensive immune system modulation during cold and flu seasons.

Liver Health Formulations: Integrated into hepatoprotective supplements due to proven efficacy against CCl4-induced liver toxicity, offering a natural alternative to Silymarin in detoxification and liver cleansing product lines.

Veterinary Medicine Applications: Applied in poultry and swine feed additives to combat respiratory diseases and bacterial infections, providing antibiotic-alternative solutions that address antimicrobial resistance concerns in livestock farming.

Cosmeceutical Ingredients: Incorporated into anti-inflammatory skincare formulations for acne treatment and skin soothing applications, leveraging its documented anti-bacterial and anti-inflammatory dermatological benefits.

Production Process

Step 1 - Sourcing the Raw Material: We pick Andrographis paniculata plants from our certified organic growing sites when alkaloid levels are highest. Production employs only premium aerial pieces with pre-tested Andrographolide content >0.8% to assure the exceptional quality of the starting material.

Step 2 - Cleaning and Preparation: Selection of raw materials, mechanical cleaning, removal of foreign matter, drying at temperatures below 60°C so that thermolabile chemicals are not destroyed. Clean and consistent dried plant material, suitable for effective extraction with little microbial burden.

Step 3 - Ethanol Extraction: Dried herbs are subjected to counter-current ethanol extraction using food-grade solvent at optimized temperature and time parameters. Result: Maximum production of Andrographolide with selective extraction of targeted bioactive chemicals leaving behind undesired plant matrix.

Step 4 - Filtration and Concentration: Extract solution passes through multi-stage filtration to remove particulates, followed by vacuum concentration at reduced temperatures. Concentrated extract solution with retained bioactivity and reduced solvent content for downstream processing.

Step 5 - Purification and Crystallization: Andrographolide is isolated from similar substances such as Dehydroandrographolide and Neoandrographolide by sophisticated chromatography techniques and controlled crystallization. Result: High purity crystalline Andrographolide with 98%+ specification with a unique HPLC fingerprint.

Step 6 - Drying & Milling: The purified crystals are vacuum dried to less than 3% moisture content, then precision milled to 80-mesh particle homogeneity. Result: Free flowing white powder with optimum flow properties for capsule filling and tablet compression applications.

Step 7 - Quality Testing & Packaging: All production batches are tested rigorously for identification, purity, heavy metals, pesticides and microbiological before being packed in double layer PE bags within fibre drums. Result: Fully documented, certified goods, ready for immediate distribution, with full COA and third party reports.

OEM/ODM Support

Custom Specification Development: Working together with you, our R&D team designs Andrographolide levels and mixed formulas that meet your unique therapeutic goals, market positioning, and regulatory needs in a variety of regions.

Comprehensive Formulation Services: We minimize your time-to-market by offering raw extracts and entire services from excipient selection and stability testing to pilot scale manufacturing of soft capsules, hard capsules, tablets and premixed powders.

Flexible Packaging Solutions: Bulk drums, smaller research quantities or bespoke retail packaging with your branding, including blister packs, bottles and sachets tailored to your marketing plan and distribution techniques.

Regulatory Documentation: Support We offer entire technical dossiers, stability data, toxicology reports and regulatory filing support for your NDI notifications, GRAS determinations or pharmaceutical drug master file submissions.

Minimum Order: We appreciate that business requirements are diverse and we can supply from 1kg for product development to multi-ton contracts for commercial manufacture with quality assured whatever the order quantity.

Why Choose Us?

Shaanxi Hongda Phytochemistry 24 years of excellence your most trusted partner to supply the products.  Our vertically integrated approach from certified organic farms to ISO-certified manufacturing provides end-to-end supply chain transparency and quality control that contract manufacturers just can’t match. Production capacity: 3,000 tons/year Over 3,000 square meters of warehouse stock We guarantee timely deliveries without sacrificing quality. We have SGS standardized laboratory with more than 20 PhD level scientists to verify each batch with 27-points of quality before delivery. We work with pharmaceutical companies, supplement brands, and veterinary product manufacturers from North America to Europe to Asia, via providing specification-grade products time and time again. Choosing Hongda is more than an extract, it is a strategic manufacturing partner devoted to the success of your product providing swift technical support and customized solutions that evolve with your company needs.

FAQ

Q: What is the difference between 10% and 98% Andrographolide extracts?

A: The 10-50% extracts have more of the entire plant ingredients which are good for broad range immune supplements. 98% pharmaceutical grade Andrographolide is great for clinical use with minimal excipients and allows for precision dosing.

Q: How do you address the water solubility of Andrographolide?

A: We may provide micronized forms and advocate co-processing with cyclodextrins or phospholipid complexes to significantly enhance solubility rates and bioavailability.

Q: What is your typical lead time for bulk orders?

A: Standard specs are shipped within 3-7 working days from our ready inventory. Custom formulas are produced and quality tested within 15-20 days.

Q: Do you supply samples for formulation testing?

A: Yes, we have 20-100g samples with full COA paperwork. Sample fees are deducted from your first commercial order over 25kg.

Q: How do you guarantee the same quality in different harvest years?

A: We have controlled planting bases using defined growing techniques and mix batches from different harvest times to provide year-round specification uniformity as proven by HPLC fingerprinting.

Contact Us

Ready to source premium Andrographis Extract Andrographolide for your next product development?

Email: duke@hongdaherb.com​​​​​​​